How to Boost the Immune System and Suppress the Cytokine Cascade Associated with COVID19 Deaths

COVID-19 infection has puzzled many epidemiologists because of the unpredictable consequences of its progression in different patients. While those with compromised health are most vulnerable, many who seem to be young and robust are also impacted, whereas others who get infected seem to improve, then exhibit a relapse followed by a rapid decline and death.

Rapid decline and death is often attributed to an immune system overreaction in the form of a cytokine cascade that causes a fatal autoimmune attack on lung tissues. While the etiology of this immune response is complex and includes several powerful interacting variables, the solution may be more straightforward than suspected.

Vaccines can amplify the response of the immune system killing the virus before it causes systemic damage. Unfortunately, there is currently no vaccine for COVID-19, leaving human immune systems without a means of strengthening its response to the viral infection.

The profile of this virus suggests that those with a powerful and healthy immune system are relatively resistant to its attack. This virus preys on the weak, those with a compromised immune system. To survive this attack, the immune response must be strong, robust and long lasting.

Eukaryotes and Prokaryotes manufacture virtually all energy requirements employing mitochondria which also make excessive reactive oxidative species (ROS) for which we have an obligate antioxidant nutritional requirement. Our evolutionary development is closely tied to our dietary requirements and the industrialization of food production has altered our nutritional profile in ways that resulted in obligate nutritional deficits that have ceased to support our health.

The lethal cytokine storm which often results in the demise of those infected with the COVID 19 virus is a manifestation of a failure mechanism in a short period of time that is found in most all chronic diseases and is based on mitochondrial dysfunction due to nutritional deficits of an obligate antioxidant requirement, highly bio available astaxanthin, as well as essential metals and amino acids

such as magnesium, selenium, iron and zinc, taurine and Omega III fatty acids such as DHA and EPA.

This failure mechanism has been identified in the past decade as the major factor in the etiology of most all chronic diseases: Alzheimer’s⁴³, Cancer⁴⁵, Parkinson’s⁴⁴, Autism⁴², Autoimmune diseases⁴⁶, ALS^47,48, SLE (Lupus)⁴⁹ have all grown by orders of magnitude in the past 50 years. These curves exactly follow the diminishment of those elements of our obligate diet as food production was industrialized and our diets altered. These curves describe nearly exactly the mitochondrial dysfunction and decline or our health through these chronic diseases. In most chronic diseases this decline, and the rise of the diseases is slow and steady and often not noticed till the end game rises like a wolf. Here are the number suffering from these diseases in the US:

Alzheimer’s 6 million

Cancer 11 million

Parkinson’s 500 thousand

Autism 3.5 million, one in 59

Autoimmune diseases 24 million

ALS 20,000

Influenza 12 to 58 million infections, 20,000 to 60,000 deaths

Most all of these are caused by nutritional deficiencies which compromise the immune and other systems. But in many if not most of these cases, the insult of this nutritional deficiency is incurred slowly, steadily and over long periods of time. The major solution to the COVID 19 pandemic is to supplement the diet of all those infected or in danger of being infected with the right mix of highly bio available lipid rich nano emulsified materials including astaxanthin, zinc, iron, selenium, magnesium, taurine, DHA and Vitamin C.

The nature of the insult is three-fold:

From an evolutionary point of view, the presence of a strong antioxidant to mitigate the reactive oxidative species (ROS) manufactured by the mitochondria can be defined as an obligate need. The lack of filling this obligate need over time is the decline of energy generating capacity.
The uncontrolled ROS due to the lack of the obligate antioxidant in the mitochondria and cell plasma membrane also cause the destruction of a wide range of materials, metals and molecules that have obligate molecular metabolic roles. Taurine, selenium, magnesium, DHA, iron, zinc can act as antioxidants, but they all have complex often pro-oxidant metabolic molecular functions for which they need to be protected.
The result is an impairment of a wide range of metabolic functions including the immune system.

In the absence of a targeted vaccine, we must rely on an often compromised and exhausted immune system to defeat the invader. We must strengthen and reinforce that immune system so that it can sustain and complete its defense and avoid a breakdown of the immune system and the resulting lethal cytokine cascade. This can be done with natural safe materials if they can be made bio available. And this can then be used to quickly boost the immune system of those at risk.

We suggest that the interacting variables of cellular biochemistry and metabolism are just now becoming well enough understood to rationally design supplements to fortify the human immune system. Part of the solution involves limiting the production of Reactive Oxidative Species (ROS) manufactured by the mitochondria as a by-product of oxidative phosphorylation. Cellular antioxidants protect several biomolecules from oxidation, and some, despite their antioxidant functions, also have important, even vital metabolic pro-oxidant roles.

The immune system’s response to a viral challenge involves a cascade of molecular processes which require energy from stored ATP, as well as a group of metals, minerals and molecules. This group can act as antioxidants, but often have pro-oxidant roles and must be protected from oxidative degradation.

Five compounds are of highest interest in this regard, and all are typified by very poor bioavailability: astaxanthin, selenium, magnesium, iron and zinc. ^{30,31,32,33,34,35,36,37}

Making astaxanthin, selenium, magnesium, iron and zinc highly bioavailable along with supplemental DHA and taurine should be the path to boosting our immune response while we wait for vaccines to emerge.

The Problem

How can we provide therapeutic doses of highly bioavailable astaxanthin, taurine, DHA, selenium, magnesium, zinc and iron to sick patients? The natural pathways are designed to be steady and build up reserves. We calculate the following dose 3-4 times per day is required to restore steady state.

Supplemental Facts per Dose of 5mL = teaspoon
Compound	Amount	Units
Astaxanthin	21.0	mg
Zinc	0.02	mg
Selenium	5	ppm
Iron	4.9	mg
Magnesium	41.4	mg
Vitamin C	16.5	mg
Taurine	194.3	mg
DHA	145.7	mg

Molecules that are attracted by water (hydrophilic molecules), are often conveyed into cells by liposomes. Molecules that repel water (hydrophobic molecules), are often transported by micelles. In both cases enormous quantities of nano-sized lipids are necessary.

The solution:We solve this problem with our lipid rich nano-emulsification, which is Adjuvia Immune Booster.

Our starting materials are made from natural materials, but in the natural form they are large and the contents we want to make available are not. For instance, here they are listed with their size at time of harvest and prior to preparation for bio availability.

Freshwater algae Haematoccocus pluvialis biomass with typically 4% astaxanthin starts out as a very tightly bound cyst of about 60 microns.
Kelp extract is a macro algae
Spirulina algae is large for a single cell organism, about 500 microns
DHA powder extracted from the alga Schizochytrium
Industrially produced taurine powders
Vitamin C powder

Algae based sources of astaxanthin, selenium, magnesium and zinc are famous for very low bioavailable profiles, but our process solves this.

The result is a nano-emulsified, lipid rich supplement that enables the rapid delivery of astaxanthin selenium, magnesium, iron andzinc directly into human cells along with DHA and vitamin C.

Authors Note: The original publication has over 25 pages of technical references. For a complete copy contact us at support@snextracts.com