Astaxanthin and Cancer Research Links as of Jan 22

Note: We have twice as many references vs. what could fit in this page. For a complete list contact info@adjuvia.life

Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells

P Palozza, C Torelli, A Boninsegna, R Simone… - Cancer letters, 2009 - Elsevier

… Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human
colon cancer cells … Abstract. The growth-inhibitory effects of the astaxanthin-rich
Haematococcus pluvialis were studied in HCT-116 colon cancer cells …

Save Cite Cited by 204 Related articles All 8 versions

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral …

K Kavitha, J Kowshik, TKK Kishore, AB Baba… - … et Biophysica Acta (BBA …, 2013 - Elsevier

… General significance. Astaxanthin targets key molecules in oncogenic signaling pathways
and induces apoptosis and is a promising candidate agent for cancer prevention and
therapy. Previous article in issue; Next article in issue. Keywords …

Save Cite Cited by 159 Related articles All 6 versions

[PDF] mdpi.com

Multiple mechanisms of anti-cancer effects exerted by astaxanthin

L Zhang, H Wang - Marine drugs, 2015 - mdpi.com

… MDPI. Get Information. clear. Open AccessReview. Multiple Mechanisms of Anti-Cancer
Effects Exerted by Astaxanthin … Keywords: astaxanthincancer; molecular targets
astaxanthincancer; molecular targets. 1. Introduction. Astaxanthin …

Save Cite Cited by 141 Related articles All 10 versions 

Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress

H Kurihara, H Koda, S Asami, Y Kiso, T Tanaka - Life sciences, 2002 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. Life Sciences. Volume 70, Issue
21, 21 April 2002, Pages 2509-2520. Life Sciences. Contribution of the antioxidative property
of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated …

Save Cite Cited by 251 Related articles All 9 versions

[HTML] mdpi.com

Effects of astaxanthin on the proliferation and migration of breast cancer cells in vitro

B McCall, CK McPartland, R Moore… - Antioxidants, 2018 - mdpi.com

… Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro … Keywords:
antioxidant; astaxanthin; breast cancer; carotenoid; migration; proliferation; Xanthoph antioxidant;
astaxanthin; breast cancer; carotenoid; migration; proliferation; Xanthoph …

Save Cite Cited by 42 Related articles All 7 versions 

Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells

PB Atalay, G Kuku, BG Tuna - In Vitro Cellular & Developmental Biology …, 2019 - Springer

… Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer
cells. Download PDF. Download PDF. Published: 13 December 2018. Effects of carbendazim
and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells …

Save Cite Cited by 17 Related articles All 7 versions

Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma

YT Chen, CJ Kao, HY Huang, SY Huang… - Journal of Functional …, 2017 - Elsevier

… Elsevier. Journal of Functional Foods. Volume 31, April 2017, Pages 20-31. Journal of Functional
Foods. Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers
apoptotic caspases of in vitro and in vivo models in melanoma …

Save Cite Cited by 38 Related articles All 7 versions

[PDF] researchgate.net

Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis

AR Rao, HN Sindhuja, SM Dharmesh… - Journal of agricultural …, 2013 - ACS Publications

… Effective Inhibition of Skin Cancer, Tyrosinase, and Antioxidative Properties by Astaxanthin and
Astaxanthin Esters from … Article Views are the COUNTER-compliant sum of full text article
downloads since November 2008 (both PDF and HTML) across all institutions …

Save Cite Cited by 176 Related articles All 11 versions

[HTML] nature.com

[HTML] Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a

HY Kim, YM Kim, S Hong - Scientific reports, 2019 - nature.com

Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated
downregulation of microRNA-29a-3p and microRNA-200a. Download PDF. Article; Open
Access; Published: 01 July 2019. Astaxanthin suppresses …

Save Cite Cited by 28 Related articles All 9 versions

Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells

JC Ko, JC Chen, TJ Wang, HY Zheng, WC Chen… - Biochemical …, 2016 - Elsevier

… However, the molecular mechanism of astaxanthin-induced cytotoxicity in non-small cell lung
cancer (NSCLC) cells has not been identified … These results may provide rationale to combine
astaxanthin with MMC for lung cancer treatment. 2. Methods. 2.1. Chemicals …

Save Cite Cited by 53 Related articles All 7 versions

[HTML] Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer

J Kowshik, AB Baba, H Giri, G Deepak Reddy, M Dixit… - PloS one, 2014 - journals.plos.org

… Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and
Angiogenesis in a Hamster Model of Oral Cancer … Astaxanthin Inhibits JAK/STAT-3 Signaling
to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer …

Save Cite Cited by 112 Related articles All 12 versions 

Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells

KS Liao, CL Wei, JC Chen, HY Zheng, WC Chen… - Regulatory Toxicology …, 2016 - Elsevier

… Highlights. • Astaxanthin decreases thymidylate synthase expression in human lung cancer cells. • …
These results may provide a rationale to combine astaxanthin with pemetrexed for lung cancer
treatment. 2. Materials and methods. 2.1. Cell lines and chemicals …

Save Cite Cited by 21 Related articles All 5 versions

[HTML] mdpi.com

[HTML] Anti-tumor effects of astaxanthin by inhibition of the expression of STAT3 in prostate cancer

SQ Sun, YX Zhao, SY Li, JW Qiang, YZ Ji - Marine Drugs, 2020 - mdpi.com

… In this study, we investigated the mechanisms of the anti-cancer effects of astaxanthin on prostate
cancer (PCa) cell lines using aggressive PCa DU145 cells … However, whether astaxanthin
suppresses prostate cancer through STAT3 is yet to be elucidated …

Save Cite Cited by 10 Related articles All 9 versions 

[PDF] mdpi.com

On a beam of light: Photoprotective activities of the marine carotenoids astaxanthin and fucoxanthin in suppression of inflammation and cancer

E CatanzaroA Bishayee, C Fimognari - Marine Drugs, 2020 - mdpi.com

… Get Information. clear. Open AccessReview. On a Beam of Light: Photoprotective Activities
of the Marine Carotenoids Astaxanthin and Fucoxanthin in Suppression of Inflammation
and Cancer … 2.1. Astaxanthin and UV-Mediated Skin Cancer …

Save Cite Cited by 7 Related articles All 11 versions 

[PDF] mdpi.com

Cytotoxic induction and photoacoustic imaging of breast cancer cells using astaxanthin-reduced gold nanoparticles

S BharathirajaP Manivasagan, N Quang Bui, YO Oh… - Nanomaterials, 2016 - mdpi.com

… and therapy. Keywords: astaxanthin; breast cancer; gold nanoparticle; cytotoxicity;
photoacoustic imaging astaxanthin; breast cancer; gold nanoparticle; cytotoxicity;
photoacoustic imaging. 1. Introduction. Nanotechnology is a …

Save Cite Cited by 23 Related articles All 9 versions 

In vitro antitumor potential of astaxanthin nanoemulsion against cancer cells via mitochondrial mediated apoptosis

K Shanmugapriya, H Kim, HW Kang - International journal of pharmaceutics, 2019 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. International Journal of
Pharmaceutics. Volume 560, 5 April 2019, Pages 334-346. International Journal of Pharmaceutics.
In vitro antitumor potential of astaxanthin nanoemulsion against cancer cells via mitochondrial …

Save Cite Cited by 29 Related articles All 5 versions

Stereoisomers of astaxanthin inhibit human colon cancer cell growth by inducing G2/M cell cycle arrest and apoptosis

X Liu, M Song, Z Gao, X Cai, W Dixon… - Journal of agricultural …, 2016 - ACS Publications

… Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth … 20. LEARN ABOUT THESE
METRICS Article Views are the COUNTER-compliant sum of full text article downloads since
November 2008 (both PDF and HTML) across all institutions and individuals …

Save Cite Cited by 37 Related articles All 5 versions

[PDF] wiley.comFull View

Astaxanthin inhibits hallmarks of cancer by targeting the PI3K/NF‐κΒ/STAT3 signalling axis in oral squamous cell carcinoma models

J Kowshik, R Nivetha, S Ranjani, P Venkatesan… - IUBMB …, 2019 - Wiley Online Library

… Research Communication. Astaxanthin inhibits hallmarks of cancer by targeting
the PI3K/NF‐κΒ/STAT3 signalling axis in oral squamous cell carcinoma models.
Jaganathan Kowshik Department of Biochemistry … PDF PDF …

Save Cite Cited by 14 Related articles All 3 versions

[HTML] mdpi.com

Astaxanthin modulates apoptotic molecules to induce death of SKBR3 breast cancer cells

MS Kim, YT Ahn, CW Lee, H Kim, WG An - Marine Drugs, 2020 - mdpi.com

… Give Feedback. Information. Visit our dedicated information section to learn more about
MDPI. Get Information. clear. Open AccessArticle. Astaxanthin Modulates Apoptotic
Molecules to Induce Death of SKBR3 Breast Cancer Cells …

Save Cite Cited by 11 Related articles All 8 versions 

[HTML] nih.gov

[HTML] Astaxanthin inhibits proliferation of human gastric cancer cell lines by interrupting cell cycle progression

JH Kim, JJ Park, BJ Lee, MK Joo, HJ Chun, SW Lee… - Gut and liver, 2016 - ncbi.nlm.nih.gov

… Published online 2015 Oct 19. doi: 10.5009/gnl15208. PMCID: PMC4849689. PMID: 26470770.
Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle
Progression … 10 Dietary astaxanthin is also effective against breast cancer …

Save Cite Cited by 30 Related articles All 19 versions

Antiproliferative potential of astaxanthin-rich alga Haematococcus pluvialis Flotow on human hepatic cancer (HepG2) cell line

S Nagaraj, MG Rajaram, P Arulmurugan… - … & Preventive Nutrition, 2012 - Elsevier

… PDFDownload. Share. Export … Volume 2, Issue 3, July–September 2012, Pages 149-153.
Biomedicine & Preventive Nutrition. Original article. Antiproliferative potential of astaxanthin-rich
alga Haematococcus pluvialis Flotow on human hepatic cancer (HepG2) cell line …

Save Cite Cited by 34 Related articles All 3 versions

[HTML] spandidos-publications.com

[HTML] Astaxanthin inhibits gemcitabine‑resistant human pancreatic cancer progression through EMT inhibition and gemcitabine resensitization

T Yan, HY Li, JS Wu, Q Niu, WH Duan… - Oncology …, 2017 - spandidos-publications.com

… Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: ) Metrics: Total PDF Downloads:
0 … a suitable combination of agents for the treatment of pancreatic cancer is required. Astaxanthin
(ASX) is able to resensitize gemcitabine‑resistant human pancreatic cancer cells …

Save Cite Cited by 20 Related articles All 9 versions

[HTML] nih.gov

[HTML] Dietary natural astaxanthin at an early stage inhibits N-nitrosomethylbenzylamine–induced esophageal cancer oxidative stress and inflammation via …

L Cui, F Xu, M Wang, L Li, T Qiao, H Cui… - OncoTargets and …, 2019 - ncbi.nlm.nih.gov

… Astaxanthin (AST) is a carotenoid pigment with strong antioxidant, anti-inflammation, and antitumor
activities. However, little is known about the effects of astaxanthin in esophageal cancer … Keywords:
astaxanthin, esophageal cancer, oxidative stress, NFκB, COX2. Introduction …

Save Cite Cited by 16 Related articles All 8 versions

[PDF] researchgate.net

Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review

I Faraone, C Sinisgalli, A OstuniMF Armentano… - Pharmacological …, 2020 - Elsevier

Save Cite Cited by 40 Related articles All 5 versions

Cellulose nanocrystals/nanofibrils loaded astaxanthin nanoemulsion for the induction of apoptosis via ROS-dependent mitochondrial dysfunction in cancer cells under …

K Shanmugapriya, H Kim, YW Lee, HW Kang - International journal of …, 2020 - Elsevier

… Highlights. • Astaxanthin based nanoemulsion was effective ROS and oxidative stress agent
in cancer cell. • CNC/[email protected] inhibit cell proliferation, thereby it induces apoptosis. •
Nanoemulsion inhibited mitochondrial membrane potential. • …

Save Cite Cited by 8 Related articles All 6 versions

[PDF] academia.edu

Haematococcus astaxanthin: applications for human health and nutrition

M Guerin, ME Huntley, M Olaizola - TRENDS in Biotechnology, 2003 - Elsevier

… Download PDFDownload. Share. Export. Advanced … More recently, astaxanthin supplementation
in rats was found to inhibit the stress-induced suppression of tumor-fighting natural killer cells
[49]. As noted earlier, astaxanthin's anti-cancer activity might be related to the …

Save Cite Cited by 1626 Related articles All 27 versions

[PDF] aacrjournals.orgFree from Publisher

Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin

T Tanaka, H Makita, M Ohnishi, H Mori, K Satoh… - Cancer research, 1995 - AACR

… during lating actions of carotenoids. I. Effects of ß-caroteneand astaxanthin on immune
carcinogenesis. Cancer J., 7: 228-237, 1994. lymphocyte functions and cell surface
marker expression in in vitro culture system. 80. Yamasaki …

Save Cite Cited by 286 Related articles All 8 versions

[HTML] biomedcentral.com

[HTML] Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells

MA FouadMM Sayed-Ahmed… - BMC …, 2021 - bmcpharmacoltoxicol.biomedcentral …

Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular
subtype of breast cancer; which showed good response to doxorubicin (DOX)-based
chemotherapy. Eugenol (EUG) and astaxanthin (AST) are natural compounds with proved …

Save Cite Cited by 4 Related articles All 10 versions 

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

A Karimian, FM Mohammadrezaei, AH Moghadam… - Acta …, 2022 - Elsevier

… View PDF; Download full issue … Effect of astaxanthin and melatonin on cell
viability and DNA damage in human breast cancer cell lines …

Save Cite All 4 versions

[HTML] springer.com

[HTML] Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

JS Park, JH Chyun, YK Kim, LL Line, BP Chew - Nutrition & metabolism, 2010 - Springer

… Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in
humans. Download PDF. Download PDF. Research; Open Access; Published: 05 March 2010 …
Background. Astaxanthin modulates immune response, inhibits cancer cell growth …

Save Cite Cited by 469 Related articles All 25 versions

Antitumor activity of astaxanthin and its mode of action

H Jyonouchi, S Sun, K Iijima, MD Gross - Nutrition and cancer, 2000 - Taylor & Francis

… Carcinogenesis 15, 15–19, 1994. 7. Tanaka, T, Makita, H, Ohnishi, M, Mori, H, Satoh, K,
et al.: Chemo- prevention of rat oral carcinogenesis by naturally occurring xantho- phylls,
astaxanthin and canthaxanthin. Cancer Res 55, 4059–4064, 1995 …

Save Cite Cited by 313 Related articles All 12 versions

[PDF] tandfonline.com

Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells

M Hormozi, S Ghoreishi… - … cells, nanomedicine, and …, 2019 - Taylor & Francis

… treat it. Studies have shown effects of astaxanthin to eradicate colorectal cancer
[15]. Here we … A study reported that daily administration of astaxanthin could be
effective in preventing colon cancer [19]. Studies have shown that …

Save Cite Cited by 37 Related articles All 8 versions

Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via blocking JAK1/STAT3 pathway

C Wu, J Zhang, T Liu, G Jiao, C Li… - Xi bao yu fen zi mian yi xue …, 2016 - europepmc.org

… [Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via
blocking JAK1/STAT3 pathway] … Abstract. Objective To investigate the anti-tumor effects of
astaxanthin on A549 lung cancer cells and the related mechanisms …

Save Cite Cited by 16 Related articles All 2 versions 

[PDF] tahomaclinic.com

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines

Y Yasui, M Hosokawa, N Mikami, K Miyashita… - Chemico-biological …, 2011 - Elsevier

… Keywords. Astaxanthin. Chemoprevention. Colorectal carcinogenesis. Inflammation. Mouse.
Abbreviations. ACF aberrant crypt foci. AOM azoxymethane. AX astaxanthin. COX-2
cyclooxygenase-2. CRC colorectal cancer. DMH 1,2-dimethylhydrazine. DSS …

Save Cite Cited by 158 Related articles All 8 versions

[PDF] tahomaclinic.com

Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the …

P NagendraprabhuG Sudhandiran - Investigational new drugs, 2011 - Springer

… Download PDF. PRECLINICAL STUDIES; Published: 30 October 2009 … Colon cancer is the third
most malignant neoplasm in the world and it remains an important cause of mortality in … Astaxanthin
(AST), a major component of carotenoids possesses attractive remedial features …

Save Cite Cited by 168 Related articles All 12 versions

[PDF] academia.edu

Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives

LM Hix, SF Lockwood, JS Bertram - Cancer letters, 2004 - Elsevier

… Previous article in issue; Next article in issue. Keywords. Astaxanthin. Carotenoids. Cancer
chemoprevention. Connexin 43. Disodium salt disuccinate astaxanthin derivatives. Gap
junctions. Synthetic astaxanthin derivatives. 1. Introduction …

Save Cite Cited by 62 Related articles All 8 versions

[PDF] mdpi.com

Astaxanthin: sources, extraction, stability, biological activities and its commercial applications—a review

RR AmbatiSM PhangS Ravi, RG Aswathanarayana - Marine drugs, 2014 - mdpi.com

… Get Information. clear. Open AccessReview. Astaxanthin: Sources, Extraction, Stability, Biological
Activities and Its Commercial Applications—A Review … 2. Source of Astaxanthin. The natural
sources of astaxanthin are algae, yeast, salmon, trout, krill, shrimp and crayfish …

Save Cite Cited by 1196 Related articles All 20 versions 

[PDF] researchgate.net

Astaxanthin: a review of its chemistry and applications

I Higuera-Ciapara, L Felix-Valenzuela… - Critical reviews in …, 2006 - Taylor & Francis

… Astaxanthin (AX) is a pigment that belongs to the family of the xanthophylls, the oxygenated
derivatives of carotenoids whose synthesis in … potential for protecting the organism against a wide
range of ailments such as cardiovascular problems, different types of cancer and some …

Save Cite Cited by 1056 Related articles All 10 versions

[HTML] nih.gov

Astaxanthin enhances erlotinib-induced cytotoxicity by p38 MAPK mediated xeroderma pigmentosum complementation group C (XPC) down-regulation in human …

JC Chen, CH Wu, YS Peng, HY Zheng… - Toxicology …, 2018 - academic.oup.com

… pdf PDF; Split View; … Yuan-Cheng Lin, Peng-Fang Ma, Ting-Chuan Yen, Tzu-Ying Chen,
Yun-Wei Lin, Astaxanthin enhances erlotinib … by p38 MAPK mediated xeroderma pigmentosum
complementation group C (XPC) down-regulation in human lung cancer cells, Toxicology …

Save Cite Cited by 9 Related articles All 6 versions

Effect of Astaxanthin on cell viability in T-47D and MDA-MB-231 Breast Cancer Cell Lines

A Karimian, A Hajizadeh Moghaddam… - … Cancer Investigation, 2017 - mcijournal.com

… In this study, the apoptotic effects of Astaxanthin on breast cancer cell lines have been investigated …
Conclusions: The research findings indicate that Astaxanthin can induce apoptosis in cancer cells
and it could be considered as a therapeutic agent in breast cancer …

Save Cite Cited by 5 Related articles All 4 versions 

Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells

X Song, J Zhang, M Wang, W Liu, X Gu… - Biological and …, 2011 - jstage.jst.go.jp

… In this study, the effect of astaxanthin on liver cancer cells and mitochondria were
investigated by using CBRH-7919 cell. It showed that, at 39M concentration,
astaxanthin significantly inhibited CBRH-7919 cell prolifera- tion …

Save Cite Cited by 87 Related articles All 7 versions

[HTML] mdpi.com

Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by Inhibiting Expression of Pontin and Mutant p53

YT Ahn, MS Kim, YS Kim, WG An - Marine Drugs, 2020 - mdpi.com

… Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by
Inhibiting Expression of Pontin and Mutant p53 … Abstract. Astaxanthin (AST) is a product made
from marine organisms that has been used as an anti-cancer supplement …

Save Cite Cited by 5 Related articles All 10 versions 

[PDF] mdpi.com

Astaxanthin inhibits PC-3 xenograft prostate tumor growth in nude mice

X Ni, H Yu, S Wang, C Zhang, S Shen - Marine drugs, 2017 - mdpi.com

… dietary supplement manner. Keywords: prostate cancerastaxanthin;
immunohistochemistry; PCR-DGGE; miRNA prostate cancerastaxanthin;
immunohistochemistry; PCR-DGGE; miRNA. 1. Introduction. Prostate cancer (PCa …

Save Cite Cited by 32 Related articles All 8 versions 

Safety of an Astaxanthin-Rich Haematococcus pluvialis Algal Extract: A Randomized Clinical Trial

GA Spiller, A Dewell - Journal of medicinal food, 2003 - liebertpub.com

… 2020. On a Beam of Light: Photoprotective Activities of the Marine Carotenoids Astaxanthin and
Fucoxanthin in Suppression of Inflammation and Cancer. Marine Drugs 18:11, 544 … 2016. FlexPro
MD, a Mixture of Krill Oil, Astaxanthin, and … [Abstract] [Full Text] [PDF] [PDF Plus] 38 …

Save Cite Cited by 196 Related articles All 5 versions

[PDF] jst.go.jp

Inhibition of low-density lipoprotein oxidation by astaxanthin

T Iwamoto, K Hosoda, R Hirano, H Kurata… - … of atherosclerosis and …, 2000 - jstage.jst.go.jp

… Astaxanthin of the xanthophyll group pos- sesses no provitamin A activity in contrast to a-carotene.
Amongst the diverse biological functions of astaxanthin are involvement in cancer prevention
(19), enhancement of immune responses (20) and free radical quenching (21-23) …

Save Cite Cited by 325 Related articles All 7 versions

[PDF] tahomaclinic.com

A preliminary investigation of the enzymatic inhibition of 5α-reductase and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and saw palmetto …

ML Anderson - Journal of Herbal Pharmacotherapy, 2005 - Taylor & Francis

… Carcinogenesis 16, 2957-2963, 1995. 14. Tanaka T, Makita H, Ohnishi M. Chemoprevention
of rat oral carcinogenesis by naturally occurring xanthophylls astaxanthin and canastaxanthin.
Cancer Res. 55, 4059- 4064, 1995. 26 JOURNAL OF HERBAL PHARMACOTHERAPY …

Save Cite Cited by 55 Related articles All 7 versions

[HTML] nih.gov

Astaxanthin-Rich Algal Meal and Vitamin C InhibitHelicobacter pylori Infection in BALB/cA Mice

X Wang, R Willén, T Wadström - Antimicrobial agents and …, 2000 - Am Soc Microbiol

… Free Radic. Biol. Med. 26:679–684. 32. Tanaka, T., H. Makita, M. Ohnishi, H. Mori, K. Satoh,
and A. Hara. 1995. Chemoprevention of rat oral carcinogenesis by naturally occurring xantho-
phylls, astaxanthin and canthaxanthin. Cancer Res. 55:4059–4064. 33 …

Save Cite Cited by 185 Related articles All 18 versions

[PDF] zerolag.com

Commercial potential for Haematococcus microalgae as a natural source of astaxanthin

RT Lorenz, GR Cysewski - Trends in biotechnology, 2000 - Elsevier

… Download PDFDownload. Share. Export. Advanced … Trends in Biotechnology. Volume 18, Issue
4, 1 April 2000, Pages 160-167. Journal home page for Trends in Biotechnology. Review.
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin …

Save Cite Cited by 1346 Related articles All 14 versions

[HTML] sciencedirect.com

[HTML] Nrf2 a molecular therapeutic target for Astaxanthin

Z Kohandel, T Farkhondeh, M Aschner… - Biomedicine & …, 2021 - Elsevier

… Download PDFDownload. Advanced … In the present review, we discuss the role of Nrf2 in mediating
the anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective,
hepatoprotective, anti-diabetic and … Astaxanthin. Nrf2. Oxidative stress. Inflammation …

Save Cite Cited by 9 Related articles All 5 versions

[PDF] researchgate.net

Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress

AM Wolf, S Asoh, H Hiranuma, I Ohsawa, K Iio… - The journal of nutritional …, 2010 - Elsevier

… Astaxanthin (AX), a red-orange carotenoid pigment, is a powerful antioxidant that
occurs naturally in a wide variety of living organisms and has positive effects on
cancer, diabetes, the immune system, and ocular health [22] …

Save Cite Cited by 183 Related articles All 10 versions

Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: role of Nrf2, p53, p38 and …

DN TripathiGB Jena - Mutation Research/Genetic Toxicology and …, 2010 - Elsevier

… Download PDFDownload … Cyclophosphamide. Astaxanthin. GST-P positive foci. Nrf2 … benign
diseases [2], [3], [4]. However, several instances of secondary malignant tumors have been
observed in patients treated with CP [5], [6]. Treatment with CP in breast cancer patients having …

Save Cite Cited by 162 Related articles All 5 versions

Astaxanthin combine with human serum albumin to abrogate cell proliferation, migration, and drug-resistant in human ovarian carcinoma SKOV3 cells

XZ Su, R Chen, CB Wang, XL Ouyang… - Anti-Cancer Agents …, 2019 - ingentaconnect.com

… Youjiang Medical University for Nationalities, 98 Chengxiang Road, Baise 533000,
China Abstract: Background: Astaxanthin (AST) shows a large range of beneficial
effects together with anti-cancer and antioxidation properties …

Save Cite Cited by 15 Related articles All 4 versions

[PDF] iiarjournals.orgFree from Publisher

Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB/c mice

R Nakao, OL Nelson, JS Park, BD Mathison… - Anticancer …, 2010 - ar.iiarjournals.org

… Cancer Diagnosis & Prognosis. More: IIAR; Conferences; 2008 Nobel Laureates. About Us:
General Policy; … Effect of Dietary Astaxanthin at Different Stages of Mammary Tumor Initiation in
BALB/c … For correspondence: boonchew@wsu.edu. Article; Figures & Data; Info & Metrics; PDF

Save Cite Cited by 55 Related articles All 7 versions

[PDF] academia.edu

Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice

DN TripathiGB Jena - Chemico-biological interactions, 2009 - Elsevier

… Download PDFDownload … Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione; AST) is
a red carotenoid pigment, which occurs in certain … including conversion of vitamin-A [1],
enhancement of immune response [2] and protection against diseases such as cancer [3]. It has …

Save Cite Cited by 158 Related articles All 8 versions

[PDF] psu.edu

Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during …

T TanakaT Kawamori, M Ohnishi, H Makita… - …, 1995 - academic.oup.com

… A activity (one-sixth that of retinol), rather than intake of vitamin A itself, seems best correlated
with decreased cancer incidence … Among carotenoids ingested by mammals, lycopene, lutein,
astaxanthin (AX), canthaxanthin (CX) and fucoxanthin are not precursors of vitamin A in …

Save Cite Cited by 168 Related articles All 12 versions

[PDF] academia.edu

Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1, 2‐dimethyl hydrazine‐induced experimental colon carcinogenesis

PN Prabhu, P Ashokkumar… - Fundamental & clinical …, 2009 - Wiley Online Library

… PDF PDF … Abstract. Colon cancer is one of the major causes of cancer mortality worldwide … In this
study, we have evaluated the chemopreventive efficacy of astaxanthin on lipid peroxidation,
antioxidant status, total number of aberrant crypt foci (ACF), and cell proliferation in 1,2 …

Save Cite Cited by 67 Related articles All 8 versions

[PDF] zerolag.com

Antioxidant activities of astaxanthin and related carotenoids

YMA Naguib - Journal of agricultural and food chemistry, 2000 - ACS Publications

… Antioxidant Activities of Astaxanthin and Related Carotenoids … Citations. 468. LEARN ABOUT
THESE METRICS Article Views are the COUNTER-compliant sum of full text article downloads
since November 2008 (both PDF and HTML) across all institutions and individuals …

Save Cite Cited by 1002 Related articles All 11 versions

[PDF] helicojournal.org

Anticancer effects of astaxanthin and alpha-tocopherol in esophageal cancer cell lines

JY Lee, WH Jung, EH Lim, MK Joo, BJ Lee… - The Korean Journal …, 2011 - helicojournal.org

… J Agric Food Chem 2000;48:1150-1154. 7. Tanaka T, Makita H, Ohnishi M, Mori H, Satoh K, Hara
A. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin
and canthaxanthin. Cancer Res 1995;55: 4059-4064. 8. Palozza P, Krinsky NI …

Save Cite Cited by 13 Related articles All 8 versions 

Kinetics for the reversible isomerization reaction of trans-astaxanthin

JP Yuan, F Chen - Food chemistry, 2001 - Elsevier

… does not have provitamin A activity (Jyonouchi et al., 1991, Jyonouchi et al., 1995, Jyonouchi
et al., 1996, Savoure et al., 1995), recent studies have demonstrated that astaxanthin has
considerable preventive activities against cancer and may be used in medicine (Gradelet et al …

Save Cite Cited by 55 Related articles All 6 versions

[PDF] scielo.br

Astaxanthin: structural and functional aspects

LMAJ SeabraLFC Pedrosa - Revista de Nutrição, 2010 - SciELO Brasil

… 7 , obesity. 8 , macular degeneration. 9 and cancer. 10,11 … The authors found no adverse effects
from high astaxanthin intake on their blood or biochemical parameters, such as albumin, globulin,
creatinine, alkaline phosphatase, alanine and … Versão para download de PDF …

Save Cite Cited by 82 Related articles All 4 versions 

[HTML] Astaxanthin and β-carotene in Helicobacter pylori-induced Gastric Inflammation: A Mini-review on Action Mechanisms

H Kang, H Kim - Journal of cancer prevention, 2017 - ncbi.nlm.nih.gov

… J Cancer Prev. 2017 Jun; 22(2): 57–61. Published online 2017 Jun 30. doi: 10.15430/JCP.2017.22.
2.57. PMCID: PMC5503216. PMID: 28698858. Astaxanthin and β-carotene in Helicobacter
pylori-induced Gastric Inflammation: A Mini-review on Action Mechanisms …

Save Cite Cited by 35 Related articles All 13 versions

[HTML] oup.com

Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts

F Daubrawa, H Sies, W Stahl - The Journal of nutrition, 2005 - academic.oup.com

… 01 November 2005. pdf PDF; Split View; … foci in chemically transformed cells (8,9). GJIC is disturbed
in most tumor cells, and restoring cell-to-cell communication may be a strategy in cancer
prevention. Astaxanthin and the structurally closely related canthaxanthin (Fig …

Save Cite Cited by 53 Related articles All 7 versions

[PDF] psu.edu

Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin

T Tanaka, Y Morishita, M Suzui, T Kojima… - …, 1994 - academic.oup.com

… 47. Jyonouchi,H., Hill.R J., Tomita,Y. and Good,RA (1991) Studies of immuno- modulating actions
of carotenoids. I. Effects of 0-carotene and astaxanthin on murine lymphocyte functions and cell
surface marker expression in in vitro culture system. Nutr. Cancer, 16, 93-105 …

Save Cite Cited by 252 Related articles All 10 versions

[PDF] jmolpat.com

Antioxidant effects of astaxanthin in various diseases??? a review

L EkpeK InakuV Ekpe - Journal of Molecular Pathophysiology, 2018 - jmolpat.com

… KEYWORDS Astaxanthin; free radical; antioxidant; cancer; carotenoids Introduction …
com/astaxanthin.html (Accessed 18 April 2018). [31] Zhang L, Wang H. Multiple mechanisms
of anti-cancer effects exerted by astaxanthin. Mar Drug 2015; 13(7):4310–30 …

Save Cite Cited by 37 Related articles All 3 versions 

[PDF] mdpi.com

Transcriptome Analysis of the Inhibitory Effect of Astaxanthin on Helicobacter pylori-Induced Gastric Carcinoma Cell Motility

SH Kim, H Kim - Marine Drugs, 2020 - mdpi.com

… and invasion. Astaxanthin (ASTX), a xanthophyll carotenoid, is known to inhibit cancer
cell migration and invasion, however the mechanism of action of ASTX in H.
pylori-infected gastric epithelial cells is not well understood. To …

Save Cite Cited by 2 Related articles All 7 versions 

[PDF] mdpi.com

Astaxanthin as a potential neuroprotective agent for neurological diseases

H Wu, H Niu, A Shao, C Wu, BJ Dixon, J Zhang, S Yang… - Marine drugs, 2015 - mdpi.com

… Give Feedback. Information. Visit our dedicated information section to learn more about MDPI.
Get Information. clear. Open AccessReview. Astaxanthin as a Potential Neuroprotective Agent
for Neurological Diseases … 2. Astaxanthin: Source, Biochemistry, Bioavailability, and Safety …

Save Cite Cited by 138 Related articles All 14 versions 

[PDF] xuebalib.com

Astaxanthin ameliorates doxorubicin-induced cognitive impairment (chemobrain) in experimental rat model: impact on oxidative, inflammatory, and apoptotic …

SE El-AgamyAK Abdel-Aziz, S Wahdan, A Esmat… - Molecular …, 2018 - Springer

… Download PDF. Download PDF. Original Paper; Published: 16 October 2017 … Chemobrain refers
to a common sequelae experienced by 15–80% of cancer patients exposed to … Astaxanthin (AST),
a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti …

Save Cite Cited by 83 Related articles All 5 versions

[PDF] cyanotech.com

[PDF] Astaxanthin and cancer chemoprevention

J Dore - Phytopharmaceuticals in Cancer Chemoprevention, 2005 - cyanotech.com

Page 1. 1 Astaxanthin and Cancer Chemoprevention John E. Dore, Ph.D … Astaxanthin as a
Potential Cancer Preventative Because astaxanthin has not typically been identified as a major
carotenoid in human serum, information on its epidemiology in human health is lacking …

Save Cite Cited by 15 Related articles All 3 versions 

[HTML] mdpi.com

[HTML] Astaxanthin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells via Inhibition of NF-κB P65 and Wnt/β-catenin in vitro

J Li, W Dai, Y Xia, K Chen, S Li, T Liu, R Zhang, J Wang… - Marine drugs, 2015 - mdpi.com

… molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has
efficient anti-oxidant, anti-inflammatory, and other activities, and has great research
prospects in cancer therapy. We selected the human hepatoma …

Save Cite Cited by 61 Related articles All 12 versions 

Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes

M Bennedsen, X Wang, R Willén, T Wadström… - Immunology letters, 2000 - Elsevier

… In some patients the disease evolves into gastric ulcer, duodenal ulcer, gastric cancer or MALT
lymphoma … We found that treatment of H. pylori infected mice with an algal cell extract containing
the antioxidant astaxanthin reduces bacterial load and gastric inflammation …

Save Cite Cited by 249 Related articles All 8 versions

staxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2–ARE pathway

CLL SawAY YangY GuoANT Kong - Food and chemical toxicology, 2013 - Elsevier

… PDFDownload. Share. Export. Advanced. Elsevier. Food and Chemical Toxicology … Abstract.
Oxidative stress is a major driver of many diseases, including cancer … Astaxanthin (AST), a red
dietary carotenoid, possesses potent antioxidant activity, and inhibits oxidative damages …

Save Cite Cited by 122 Related articles All 9 versions

[HTML] oup.com

Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative

LM Hix, DA Frey, MD McLaws, M Østerlie… - …, 2005 - academic.oup.com

… 21 April 2005. Accepted: 03 May 2005. Published: 11 May 2005. pdf PDF; Split View; … been
implicated in numerous epidemiological studies as being protective against cancer at many …
Astaxanthin (AST), primarily a carotenoid of marine origin, responsible for the pink coloration …

Save Cite Cited by 49 Related articles All 9 versions

[HTML] spandidos-publications.com

[HTML] Astaxanthin induces NADPH oxidase activation and receptor‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells

S Kim, H Lee, JW Lim, H Kim - Molecular Medicine …, 2021 - spandidos-publications.com

… Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: ) Metrics: Total PDF Downloads:
0 … Astaxanthin (ASX), a red‑colored xanthophyll carotenoid, functions as an antioxidant or … Reactive
oxygen species (ROS) promote cancer cell death by necroptosis mediated by …

Save Cite All 10 versions

Different Effects of Microwave and Ultrasound on the Stability of (all-E)-Astaxanthin

L Zhao, G Zhao, F Chen, Z Wang, J Wu… - Journal of agricultural …, 2006 - ACS Publications

… Different Effects of Microwave and Ultrasound on the Stability of (all-E)-Astaxanthin … Article
Views are the COUNTER-compliant sum of full text article downloads since November
2008 (both PDF and HTML) across all institutions and individuals …

Save Cite Cited by 147 Related articles All 7 versions

Encapsulation of Haematococcus pluvialis using chitosan for astaxanthin stability enhancement

P Kittikaiwan, S Powthongsook, P Pavasant… - Carbohydrate …, 2007 - Elsevier

… PDFDownload. Share. Export … Its antioxidant activity is approximately 100 times higher than that
of β-tocopherol, and can be used as a potential agent against cancerAstaxanthin can easily
be degraded by thermal or oxidative processes during the manufacture and storage …

Save Cite Cited by 76 Related articles All 6 versions

[HTML] nih.gov

The Promising Effects of Astaxanthin on Lung Diseases

J ChengA Eroglu - Advances in Nutrition, 2021 - academic.oup.com

… Navigation. The Promising Effects of Astaxanthin on Lung Diseases. Junrui Cheng,
Junrui Cheng. Plants for Human Health Institute, North Carolina State University. ,
Kannapolis, NC, USA. Search for other works by this author on …

Save Cite Cited by 6 Related articles All 4 versions

[PDF] mdpi.com

Low Dose Astaxanthin Treatments Trigger the Hormesis of Human Astroglioma Cells by Up-Regulating the Cyclin-Dependent Kinase and Down-Regulated the Tumor …

J Shin, RK Saini, JW Oh - Biomedicines, 2020 - mdpi.com

… Abstract. Astaxanthin (AXT) is a xanthophyll carotenoid known to have potent
anti-cancer effects via upregulation of the intracellular reactive oxygen species (ROS)
levels, which triggers apoptosis of cancer cells. While several …

Save Cite Cited by 4 Related articles All 7 versions 

[HTML] nih.gov

[HTML] Astaxanthin in liver health and disease: a potential therapeutic agent

J Li, C Guo, J Wu - Drug Design, Development and Therapy, 2020 - ncbi.nlm.nih.gov

… an antioxidant to treat brain injury and cardiovascular diseases, and has been extensively studied
in clinical practice.4,30 In addition, astaxanthin has shown anti-cancer effects in many cancers,
including liver cancer, colon cancer, bladder cancer, oral cancer and leukemia.3,31 …

Save Cite Cited by 14 Related articles All 5 versions

[PDF] researchgate.net

Astaxanthin, oxidative stress, inflammation and cardiovascular disease

RG FassettJS Coombes - Future cardiology, 2009 - Future Medicine

… Astaxanthin, oxidative stress, inflammation and cardiovascular disease … Astaxanthin.
Astaxanthin is a xanthophyll carotenoid, and unlike other carotenoids it contains
two additional oxygenated groups on each ring structure, as …

Save Cite Cited by 175 Related articles All 7 versions

[PDF] mdpi.com

Antitumour effects of astaxanthin and adonixanthin on glioblastoma

S Tsuji, S Nakamura, T Maoka, T Yamada, T Imai… - Marine drugs, 2020 - mdpi.com

… It is known that astaxanthin has antitumour effects against oral cancer, bladder carcinogenesis,
colon carcinogenesis, leukaemia, and hepatocellular carcinoma [19,20,21,22,23]; however, the
mechanisms for this antitumour activity of astaxanthin are yet to be fully clarified …

Save Cite Cited by 9 Related articles All 8 versions 

[HTML] Anti-migration and invasion effects of astaxanthin against A172 human glioblastoma cell line

T Siangcham, P Vivithanaporn… - … Journal of Cancer …, 2020 - ncbi.nlm.nih.gov

… Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic
caspases of in vitro and in vivo models in melanoma … [PubMed] [Google Scholar]; Zhang L, Wang
H. Multiple mechanisms of anti-cancer effects exerted by astaxanthin. Mar Drugs …

Save Cite Cited by 3 Related articles All 6 versions

[PDF] weizaowang.com

Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats

JS Stewart, Å Lignell, A Pettersson, E Elfving… - Food and Chemical …, 2008 - Elsevier

… Elsevier. Food and Chemical Toxicology. Volume 46, Issue 9, September 2008, Pages
3030-3036. Food and Chemical Toxicology. Safety assessment of astaxanthin-rich microalgae
biomass: Acute and subchronic toxicity studies in rats … 3.2. Plasma concentration of astaxanthin …

Save Cite Cited by 111 Related articles All 10 versions

Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin

X Song, M Wang, L Zhang, J Zhang… - Toxicology …, 2012 - Taylor & Francis

… Astaxanthin (AST), a xanthophyll carotenoid, is an extremely hydrophobic antioxidant with a high
membrane-partitioning coefficient (Sacconi et al … growth and viability, induces tumor cell apoptosis,
and inhibits tumor cell proliferation and differentiation in various cancer cell lines …

Save Cite Cited by 43 Related articles All 3 versions

Protective effect of astaxanthin on the promotion of cancer metastases in mice treated with restraint-stress

ZB Yang, S Asami, Y Toyoda, W Hujii… - Journal of Japanese …, 1997 - agris.fao.org

… 423. End Page : 428. All titles : " Protective effect of astaxanthin on the promotion of cancer
metastases in mice treated with restraint-stress " … Back. Written Paper. Protective effect of
astaxanthin on the promotion of cancer metastases in mice treated with restraint-stress [1997] …

Save Cite Cited by 11 Related articles All 2 versions 

[PDF] academia.edu

Metabolic engineering of astaxanthin production in tobacco flowers

V Mann, M Harker, I Pecker, J Hirschberg - Nature biotechnology, 2000 - nature.com

Metabolic engineering of astaxanthin production in tobacco flowers. Download PDF. Published:
August 2000. Metabolic engineering of astaxanthin production in tobacco flowers …

Save Cite Cited by 303 Related articles All 14 versions

Preventing the thermal degradation of astaxanthin through nanoencapsulation

A Tachaprutinun, T Udomsup, C Luadthong… - International journal of …, 2009 - Elsevier

… Recently, the application of astaxanthin as a nutraceutical (Hussein et al., 2006, Guerin et al.,
2003) and a medicinal ingredient for the prevention and treatment of various diseases such as
cancer (Tanaka et al., 1995, Jyonouchi et al., 2000, Nishino et al., 2005), age-related …

Save Cite Cited by 116 Related articles All 9 versions

Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice

H Heidari Khoei, S FakhriS Parvardeh… - Toxin …, 2019 - Taylor & Francis

… MTX. Astaxanthin (AST), a red-orange xanthophyll carotenoid, owns various clinical
benefits and pharmacological effects including antioxidant, anti-tumor, anti-cancer,
anti-diabetic, and anti-inflammatory properties. Since there …

Save Cite Cited by 24 Related articles All 4 versions

[HTML] nih.gov

Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro

DH Lee, CS Kim, YJ Lee - Food and chemical toxicology, 2011 - Elsevier

… Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4, 4′-dione, AST; see the chemical structure in
Fig … conversion to vitamin A (Bendich and Olson, 1989), enhancement of immune response
(Jyonouchi et al., 1994), and protection against diseases such as cancer by scavenging of …

Save Cite Cited by 186 Related articles All 13 versions

Biomedical Potential of Astaxanthin from Novel Endophytic Pigment Producing Bacteria Pontibacter korlensis AG6

A Pachaiyappan, G Sadhasivam, M Kumar… - Waste and Biomass …, 2021 - Springer

… from Novel Endophytic Pigment Producing Bacteria Pontibacter korlensis AG6. Download PDF.
Download PDF … Further tested for its cytotoxic effect on human breast cancer cell line (MCF-7)
at … The pigment present was identified as astaxanthin in the strain OP2 was purified in …

Save Cite Cited by 3 Related articles All 2 versions

[PDF] researchgate.net

… appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3′ R/S isomers of astaxanthin …

GN Coral-Hinostroza, T Ytrestøyl, B Ruyter… - … and Physiology Part C …, 2004 - Elsevier

… PDFDownload … Absorption. Astaxanthin diesters. Astaxanthin E/Z isomers. Astaxanthin R/S isomers.
Carotenoids. Lipoproteins. Pharmacokinetics. Plasma. Stereoisomers … Thus, pharmacological
doses of β,β-carotene have been shown to increase cancer incidence with smokers …

Save Cite Cited by 138 Related articles All 5 versions

Astaxanthin: A mechanistic review on its biological activities and health benefits

S Fakhri, F Abbaszadeh, L DargahiM Jorjani - Pharmacological research, 2018 - Elsevier

Save Cite Cited by 175 Related articles All 6 versions

[PDF] bonaloka.cz

Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture

NM Lyons, NM O'Brien - Journal of dermatological science, 2002 - Elsevier

… Abstract. UV radiation from sunlight is the most potent environmental risk factor in skin cancer
pathogenesis … The protective effects of the proprietary algal extract, which contained a high level
of the carotenoid astaxanthin, were compared with synthetic astaxanthin …

Save Cite Cited by 186 Related articles All 16 versions

[PDF] cambridge.orgFull View

Pharmacokinetics and first-pass metabolism of astaxanthin in rats

HD Choi, HE Kang, SH Yang, MG Lee… - British journal of …, 2011 - cambridge.org

… number of health benefits. Like other carotenoids, astaxanthin has antioxidant, anti-
cancer and anti-inflammatory activities(1). However, astax- anthin's most beneficial
property is its activity as a potent antioxidant. Miki(2) reported …

Save Cite Cited by 66 Related articles All 8 versions

Epigenetic CpG methylation of the promoter and reactivation of the expression of GSTP1 by Astaxanthin in human prostate LNCaP cells

Y Yang, F Fuentes, L Shu, C WangD Pung, W Li… - The AAPS journal, 2017 - Springer

… Download PDF … GSTP1 methylation alterations can also be detected in histologically
negative biopsy samples and can be used to improve the sensitivity of the standard histology
workup for prostate cancer detection (22) … Astaxanthin (AST; Fig …

Save Cite Cited by 18 Related articles All 5 versions

[PDF] psu.edu

[PDF] Astaxanthin: A potential carotenoid

J Dhankhar, SS Kadian, A Sharma - International journal of …, 2012 - Citeseer

… Thus, it is hypothesized that carotenoids affect DNA regulating RNA responsible for
gap-junction communications and that this role in cell-gap junctions communications
might explain some of the anti-cancer activities of astaxanthin …

Save Cite Cited by 57 Related articles All 6 versions 

Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ

L Cui, Z Li, F Xu, Y Tian, T Chen, J Li, Y Guo… - … and Cancer, 2021 - Taylor & Francis

… has a poor prognosis. The aim of this study is to explore the chemoprevention effect
of Astaxanthin (AST) and reveal the possible mechanism of AST on the development
of esophageal cancer based on PPARγ. We found that a …

Save Cite Cited by 1 All 3 versions

Effect of Astaxanthin on the Hepatotoxicity, Lipid Peroxidation and Antioxidative Enzymes in the Liver of CCl

JO Kang, SJ Kim, H Kim - Methods Find. Exp. Clin. Pharmacol, 2001 - journals.prous.com

… Am J Clin Nutr 1991, 53: 238S-46S. 7. Tanaka T., Makita, H., Ohnishi, M., Mori, H., Satoh,
K., Hara, A. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls,
astaxanthin and canthaxanthin. Cancer Res 1995, 55: 4059-64 …

Save Cite Cited by 119 Related articles All 8 versions

[PDF] researchgate.net

Potential health‐promoting effects of astaxanthin: a high‐value carotenoid mostly from microalgae

JP Yuan, J Peng, K Yin, JH Wang - Molecular nutrition & food …, 2011 - Wiley Online Library

… PDF PDF … Copy URL. Share a link. Share on: Email; Facebook; Twitter; Linked In; Reddit; Wechat.
Abstract. The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis,
Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma …

Save Cite Cited by 598 Related articles All 11 versions

[PDF] mdpi.com

Astaxanthin in skin health, repair, and disease: A comprehensive review

S Davinelli, ME Nielsen, G Scapagnini - Nutrients, 2018 - mdpi.com

… The ketocarotenoid astaxanthin (ASX), 3,30-dihydroxy-b,b-carotene-4,40-dione, was originally
isolated from a lobster by Kuhn … particular, ASX has been reported to exhibit multiple biological
activities to preserve skin health and achieve effective skin cancer chemoprevention [9 …

Save Cite Cited by 206 Related articles All 17 versions 

Biotechnology of Astaxanthin Production in Phaffia rhodozyma

EA Johnson, WA Schroeder - 1996 - ACS Publications

… Reddit; Email. PDF (1 MB). Go to Biotechnology for Improved Foods and Flavors. Abstract.
Carotenoids have recently received considerable interest because of their potential in delaying
or preventing degenerative diseases such as heart disease, cancer, and aging. Astaxanthin …

Save Cite Cited by 34 Related articles All 2 versions

[PDF] … , is one of the largest producers of carotenoids. The major composition of carotenoid on algae are β-carotene, astaxanthin, luthein, zeaxanthin, cryptoxanthin …

H de Fretes, AB Susanto, B Prasetyo… - Jurnal Teknologi dan …, 2012 - researchgate.net

… The major composition of carotenoid on algae are β- carotene, astaxanthin, luthein, zeaxanthin,
cryptoxanthin, and fucoxanthin which have … from algae has been proven as a powerful antioxidant
and may prevent some degenerative diseases, cardiovascular, and cancer …

Save Cite Cited by 39 Related articles

Isomerization of trans-Astaxanthin Induced by Copper(II) Ion in Ethanol

L Zhao, F Chen, G Zhao, Z Wang… - Journal of agricultural …, 2005 - ACS Publications

… Isomerization of trans-Astaxanthin Induced by Copper(II) Ion in Ethanol … 29. LEARN ABOUT THESE
METRICS Article Views are the COUNTER-compliant sum of full text article downloads since
November 2008 (both PDF and HTML) across all institutions and individuals …

Save Cite Cited by 46 Related articles All 7 versions

Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells

JH Kim, SW Nam, BW Kim, WJ Kim, YH Choi - Food and Chemical …, 2010 - Elsevier

… Astaxanthin also has antioxidant properties and other metabolic functions in animals, including
conversion to vitamin A (Bendich and Olson, 1989 … response (Jyonouchi et al., 1994, Okai and
Higashi-Okai, 1996), and protection against diseases such as cancer (Tanaka et al …

Save Cite Cited by 43 Related articles All 9 versions

Astaxanthin Accumulation in the Green Alga Haematococcus pluvialis: Effects of Cultivation Parameters

P He, J Duncan, J Barber - Journal of Integrative Plant Biology, 2007 - Wiley Online Library

… Studies of the cancer-preventative properties of astaxanthin have been car- ried out on rats and
mice (Tanaka et al. 1994, 1995) … Chemoprevention of rat oral carcinogenesis by naturally occur-
ring xanthophylls, astaxanthin and canthaxanthin. Cancer Res. 55, 4059–4064 …

Save Cite Cited by 83 Related articles All 3 versions

Isolation of astaxanthin monoesters from the microalgae Haematococcus pluvialis by high performance countercurrent chromatography (HPCCC) combined with high …

T Fábryová, L Tůmová, DC da Silva, DM Pereira… - Algal Research, 2020 - Elsevier

… Astaxanthin esterified with oleic acid is cytotoxic to gastric cancer cells. Abstract … Nonetheless,
esterified astaxanthins have been reported to exert better anti-ulcer, anti-skin cancer,
skin-lightening, hepatoprotective and antioxidant properties than free astaxanthin [11,12,13] …

Save Cite Cited by 13 Related articles All 3 versions

Dietary astaxanthin enhances immune response in dogs

BP Chew, BD Mathison, MG Hayek… - Veterinary Immunology …, 2011 - Elsevier

… and Immunopathology. Research paper. Dietary astaxanthin enhances immune
response in dogs … Abstract. No information is available on the possible role of
astaxanthin on immune response in domestic canine. Female Beagle …

Save Cite Cited by 94 Related articles All 7 versions

Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism

X Liu, T Shibata, S Hisaka, T Osawa - Brain research, 2009 - Elsevier

… In addition to these, several other biologic activities of astaxanthin, including
anti-cancer, anti-inflammatory, anti-diabetic, immunomodulatory activities and a
neuroprotective effect, also have been reported (Hussein et al., 2006) …

Save Cite Cited by 149 Related articles All 8 versions

Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats

JH Kim, YS Kim, GG Song, JJ Park, HI Chang - European Journal of …, 2005 - Elsevier

… Download PDFDownload … immune response (Jyonouchi et al., 1994, Okai and Higashi-Okai,
1996), and protection against diseases such as cancer by scavenging … The antioxidant activity
of astaxanthin has been reported to be approximately 10 times stronger than that of other …

Save Cite Cited by 94 Related articles All 11 versions

[PDF] dergipark.org.tr

[PDF] Selective Cytotoxic Effect of Astaxanthin on Human Lung and Colon Cancer Cells

S DEMİREA DEMİR… - … Sütçü İmam Üniversitesi …, 2020 - dergipark.org.tr

… Keywords Astaxanthin Cancer Cell culture Cytotoxicity Astaksantinin İnsan Akciğer ve Kolon
Kanseri Hücrelerindeki Seçici Sitotoksik Etkisi … antitumor potential of astaxanthin nanoemulsion
against cancer cells via mitochondrial mediated apoptosis. Int J Pharm, 560: 334-346 …

Save Cite Cited by 2 Related articles All 9 versions 

Astaxanthin, a carotenoid with potential in human health and nutrition

G Hussein, U Sankawa, H Goto… - Journal of natural …, 2006 - ACS Publications

… compliant sum of full text article downloads since November 2008 (both PDF and HTML … of 1,
including its antioxidative and anti-inflammatory properties, its effects on cancer, diabetes, the …
of 1, emphasizing our experimental data on the effects of dietary astaxanthin on blood …

Save Cite Cited by 732 Related articles All 10 versions

Effect of astaxanthin on activation of autophagy and inhibition of apoptosis in Helicobacter pylori-infected gastric epithelial cell line AGS

H Lee, JW Lim, H Kim - Nutrients, 2020 - mdpi.com

… AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are
involved in the regulation of autophagy. Astaxanthin (AST) is a potent anti-oxidant that
plays anti-inflammatory and anti-cancer roles in various cells …

Save Cite Cited by 12 Related articles All 9 versions 

[HTML] koreamed.org

[HTML] Nephroprotective effect of astaxanthin against trivalent inorganic arsenic-induced renal injury in wistar rats

X Wang, H Zhao, Y Shao, P Wang… - Nutrition research …, 2014 - synapse.koreamed.org

… Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production
in vivo and in vitro … Kobayashi Y, Hayakawa T, Kanno S, Yamamoto M, Hirano S. Subchronic
exposure to arsenic through drinking water alters expression of cancer-related genes …

Save Cite Cited by 48 Related articles All 25 versions 

Astaxanthin: health benefits and toxicity

T Satoh - Nutraceuticals, 2016 - Elsevier

… Download PDFDownload … chain is also responsible for ATX's potent antioxidant effects, which
have been verified in numerous studies and which makes it useful in the treatment of
cardiovascular, immune, inflammatory, cancer, and neurodegenerative … Astaxanthin (ATX) chain …

Save Cite Cited by 8 Related articles All 2 versions

[PDF] academia.edu

Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells

DN TripathiGB Jena - Toxicology, 2008 - Elsevier

… PDFDownload. Share. Export. Advanced. Elsevier. Toxicology. Volume 248, Issues 2–3, 27 June
2008, Pages 96-103. Toxicology … Studies in experimental animals and cell lines have confirmed
the cancer chemopreventive activity of astaxanthin (Hix et al., 2005) …

Save Cite Cited by 160 Related articles All 8 versions

[HTML] springer.com

[HTML] Effects of astaxanthin supplementation on chemically induced tumorigenesis in Wistar rats

AF GalS Andrei, C Cernea, M Taulescu… - Acta Veterinaria …, 2012 - Springer

… Download PDF. Research; Open Access; Published: 30 August 2012 … 2. Tanaka T, Makita H,
Ohnishi M, Mori H, Satoh K, Hara A: Chemoprevention of rat oral carcinogenesis by naturally
occurring xanthophylls, astaxanthin and canthaxanthin. Cancer Res. 1995, 55: 4059-4064 …

Save Cite Cited by 19 Related articles All 20 versions

[PDF] jst.go.jp

Antihypertensive and neuroprotective effects of astaxanthin in experimental animals

G Hussein, M Nakamura, Q Zhao, T Iguchi… - Biological and …, 2005 - jstage.jst.go.jp

… as carotenoids, might protect against CVD15,16) and help to prevent several human diseases
such as prostate cancer and inflammatory disorders.12) In this study, we first investigated the
effects of ASX on hypertension in rats in vivo. A dietary product of astaxanthin (ASX-O …

Save Cite Cited by 244 Related articles All 18 versions

[PDF] core.ac.uk

Astaxanthin from shrimp efficiently modulates oxidative stress and allied cell death progression in MCF-7 cells treated synergistically with β-carotene and lutein from …

PRR Sowmya, BP Arathi, K Vijay, V Baskaran… - Food and Chemical …, 2017 - Elsevier

… combined effects of hydrocarbon and oxygenated carotenoids as a potential anti-cancer
therapeutic mixture … Fig. 1. Structure of carotenoids used in the present study. 2. Materials and
methods. 2.1. Chemicals. Standard β-carotene (98%), lutein (99%), astaxanthin (99%), bovine …

Save Cite Cited by 39 Related articles All 8 versions

Astaxanthin protects lipopolysaccharide-induced inflammatory response in Channa argus through inhibiting NF-κB and MAPKs signaling pathways

MY Li, L Sun, XT Niu, XM Chen, JX Tian… - Fish & shellfish …, 2019 - Elsevier

… Full length article. Astaxanthin protects lipopolysaccharide-induced inflammatory response in
Channa argus through inhibiting NF-κB and MAPKs signaling pathways … 2.2.3. Ex vivo effect of
astaxanthin against LPS-induced inflammatory in C. argus hepatocyte …

Save Cite Cited by 37 Related articles All 8 versions

Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications

SN Zarneshan, S FakhriMH FarzaeiH Khan… - Food and Chemical …, 2020 - Elsevier

Save Cite Cited by 14 Related articles All 6 versions

Biocompatible astaxanthin as novel contrast agent for biomedical imaging

VP NguyenS ParkJ Oh… - Journal of …, 2017 - Wiley Online Library

… PDF PDF … reconstruction. Further investigations on selective tumor targeting are
required to validate astaxanthin as a potential biocompatible contrast agent for
PAI-assisted bladder cancer detection. figure. Introduction. In …

Save Cite Cited by 12 Related articles All 3 versions

Interactions between irradiance and nutrient availability during astaxanthin accumulation and degradation in Haematococcus pluvialis

J Fábregas, A DominguezA Maseda… - Applied microbiology and …, 2003 - Springer

… Search SpringerLink Search. Interactions between irradiance and nutrient availability during
astaxanthin accumulation and degradation in Haematococcus pluvialis. Download PDF.
Download PDF. Original Paper; Published: 14 January 2003 …

Save Cite Cited by 110 Related articles All 15 versions

Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice

W Aoi, Y Naito, K Sakuma, M Kuchide… - … and Redox Signaling, 2003 - liebertpub.com

… antigens. Nutr Cancer 21: 47–58, 1994. 14. Kobayashi M. In vivo antioxidant role
of astaxanthin under oxidative stress in the green alga Haematococcus pluvi- alis.
Appl Microbiol Biotechnol54: 550–555, 2000. 15. Maughan …

Save Cite Cited by 231 Related articles All 6 versions

De novo synthesis of astaxanthin: From organisms to genes

N Fang, C Wang, X Liu, X Zhao, Y Liu, X Liu… - Trends in Food Science …, 2019 - Elsevier

… inRegister. Journals & Books. Help. Download PDFDownload. Share. Export. Advanced. Elsevier.
Trends in Food Science & Technology. Volume 92, October 2019, Pages 162-171. Trends in
Food Science & Technology. Review. De novo synthesis of astaxanthin: From organisms …

Save Cite Cited by 36 Related articles All 5 versions

[HTML] sciencedirect.com

[HTML] The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats

G AkcaH ErenL TumkayaT Mercantepe… - Biomedicine & …, 2018 - Elsevier

… The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats … Abstract.
Purpose. The aim of this experimental study was to investigate the antioxidant effects of
astaxanthin against cisplatin-induced nephrotoxicity in rats. Methods …

Save Cite Cited by 32 Related articles All 6 versions

Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: Astaxanthin, a carotenoid without vitamin a activity …

H Jyonouchi, S Sun, M Gross - 1995 - Taylor & Francis

… Page 13. Effects of ß-Carotene and Astaxanthin on Murine Lymphocyte Functions and Cell Surface
Marker Expression in In VitroCulture System." Nutr Cancer 16, 93-105, 1991. 15. Jyonouchi, H,
Zhang, L, and Tomita, Y: "Studies of Immunomodulating Actions of Carotenoids. II …

Save Cite Cited by 171 Related articles All 8 versions

Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T-helper cell clones and suboptimal doses of antigen

H Jyonouchi, S Sun, Y Tomita… - The Journal of nutrition, 1995 - academic.oup.com

… This may be associated with increased frequency of infections, cancer and autoimmunity in senior
citi zens. Astaxanthin's enhancing action on secondary immune responses may have a potential
role in older individuals, partially restoring specific Ab responses …

Save Cite Cited by 149 Related articles All 8 versions

[HTML] sciencedirect.com

[HTML] Astaxanthin restores the enzymatic antioxidant profile in salivary gland of alloxan-induced diabetic rats

MF Leite, AM de Lima, MM Massuyama, R Otton - Archives of oral biology, 2010 - Elsevier

… Elsevier. Archives of Oral Biology. Volume 55, Issue 7, July 2010, Pages 479-485. Archives
of Oral Biology. Astaxanthin restores the enzymatic antioxidant profile in salivary gland of
alloxan-induced diabetic rats … 2.2. Animals and astaxanthin treatment …

Save Cite Cited by 32 Related articles All 8 versions

The present perspective of astaxanthin with reference to biosynthesis and pharmacological importance

G Goswami, S Chaudhuri, D Dutta - World Journal of Microbiology and …, 2010 - Springer

… Take part in our 30 minute study now. Download PDF. Review; Published: 14 March 2010 …
Astaxanthin acts as a free-radical scavenger and an immunomodulator. It is a medicinal ingredient
against degenerative diseases such as cancer, skin related illness, and heart disease …

Save Cite Cited by 52 Related articles All 9 versions

[PDF] psu.edu

The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae)

S Qin, GX Liu, ZY Hu - Process biochemistry, 2008 - Elsevier

… Download PDFDownload … used in feed as colorant [1]. It has superior antioxidative activity [2],
potential inhibitory action to the proliferation of some cancer cells [3], and correlation with the
enhancement of T-cell activity in human [4]. For the production of astaxanthin, green alga …

Save Cite Cited by 108 Related articles All 7 versions

[HTML] nih.gov

Production of the Carotenoids Lycopene, β-Carotene, and Astaxanthin in the Food Yeast Candida utilis

Y Miura, K Kondo, T Saito, H Shimada… - Applied and …, 1998 - Am Soc Microbiol

… Recently, carotenoids have attracted greater attention, due to their beneficial effect on human
health: eg, the func- tions of lycopene and astaxanthin include strong quenching of singlet oxygen
(12), involvement in cancer prevention (2), and enhancement of immune responses …

Save Cite Cited by 235 Related articles All 14 versions

Astaxanthin as a peroxisome proliferator-activated receptor (PPAR) modulator: Its therapeutic implications

CI Choi - Marine drugs, 2019 - mdpi.com

… and lipid homeostasis, PPARγ is also associated with inflammatory responses, cardiovascular
diseases, neurogenerative diseases, ocular diseases, and cancer [11] … Astaxanthin (ASX;
3,3′-dihydroxy-β,β-carotene-4,4′-dione) (Figure 1) is a lipid-soluble, red-orange-colored …

Save Cite Cited by 26 Related articles All 6 versions 

Astaxanthin-alpha tocopherol nanoemulsion formulation by emulsification methods: Investigation on anticancer, wound healing, and antibacterial effects

K Shanmugapriya, H Kim, PS Saravana… - Colloids and Surfaces B …, 2018 - Elsevier

… Astaxanthin is a natural pigment carotenoid that belongs to xanthophylls or
oxygenated carotenoids. It can protect the human body against neurodegenerative
conditions, ultraviolet light effects, and cancer. The previous toxicity …

Save Cite Cited by 27 Related articles All 6 versions

[HTML] nih.gov

[HTML] Astaxanthin Inhibits Helicobacter pylori-induced Inflammatory and Oncogenic Responses in Gastric Mucosal Tissues of Mice

H Han, JW Lim, H Kim - Journal of Cancer Prevention, 2020 - ncbi.nlm.nih.gov

… Astaxanthin, a pinkish antioxidant carotenoid, abundant in marine organisms, is known for its
protective effect against inflammation and multiple types of cancer … Astaxanthin has attracted
substantial interest due to its anti-inflammatory and anti-cancer effects [17] …

Save Cite Cited by 6 Related articles All 10 versions

[HTML] nih.gov

[HTML] Astaxanthin prevents decreases in superoxide dismutase 2 level and superoxide dismutase activity in helicobacter pylori-infected gastric epithelial cells

SH Kim, JW Lim, H Kim - Journal of cancer prevention, 2019 - ncbi.nlm.nih.gov

… J Cancer Prev. 2019 Mar; 24(1): 54–58. Published online 2019 Mar 30. doi: 10.15430/JCP.
2019.24.1.54. PMCID: PMC6453584. PMID: 30993096. Astaxanthin Prevents Decreases in
Superoxide Dismutase 2 Level and Superoxide Dismutase Activity in Helicobacter pylori …

Save Cite Cited by 10 Related articles All 11 versions

Biotechnological applications for the sustainable use of marine by-products: In vitro antioxidant and pro-apoptotic effects of astaxanthin extracted with supercritical CO …

CM Messina, S Manuguerra, G Renda, A Santulli - Marine Biotechnology, 2019 - Springer

… Download PDF. Original Article; Published: 11 May 2019 … correlated with a lowered risk of a
number of degenerative disorders such as cancer, cardiovascular, or … Astaxanthin is one of the
most commonly found carotenoids within the marine environment which has demonstrated …

Save Cite Cited by 12 Related articles All 9 versions

[PDF] researchgate.net

Synthetic astaxanthin is significantly inferior to algal-based astaxanthin as an antioxidant and may not be suitable as a human nutraceutical supplement

B Capelli, D Bagchi, GR Cysewski - Nutrafoods, 2013 - Springer

… H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H, Tada N (2010) Administration of natural
astaxanthin increases serum … Albanes D (1994) The effect of vitamin E and beta carotene on the
incidence of lung cancer and other … http://ec.europa.eu/food/fs/ sc/scan/out81_en.pdf …

Save Cite Cited by 132 Related articles All 5 versions

Microencapsulation of astaxanthin with blends of milk protein and fiber by spray drying

Q Shen, SY Quek - Journal of Food Engineering, 2014 - Elsevier

… Research have demonstrated positive effect between astaxanthin and a number of health
conditions, such as cancer, age-related macular degeneration, inflammation and cardiovascular
oxidative stress (Tanaka et al., 1995, Pashkow et al., 2008, Willcox et al., 2008), as well as …

Save Cite Cited by 95 Related articles All 7 versions

Modulation of UVA light-induced oxidative stress by β-carotene, lutein and astaxanthin in cultured fibroblasts

I O'Connor, N O'Brien - Journal of Dermatological Science, 1998 - Elsevier

… β-Carotene was ineffective in preventing the occurrence of a secondary carcinoma in patients
who previously had skin cancer [3]. In summary, our findings suggest that carotenoids other than
β-carotene, and in particular, astaxanthin may be of importance as biological …

Save Cite Cited by 168 Related articles All 7 versions

Astaxanthin Encapsulated in Biodegradable Calcium Alginate Microspheres for the Treatment of Hepatocellular Carcinoma In Vitro

X Zhang, W Li, X Dou, D Nan, G He - Applied biochemistry and …, 2020 - Springer

… Download PDF. Published: 07 December 2019 … As suggested above, AST could be a very
promising therapeutic agent of liver cancer in clinical trials … Astaxanthin (3,3′-dihydroxy-β,β-
carotene-4,4′-dione), one of the most common red dietary carotenoids and a powerful …

Save Cite Cited by 6 Related articles All 6 versions

[PDF] mdpi.com

Astaxanthin and other nutrients from Haematococcus pluvialis—Multifunctional applications

M Mularczyk, I Michalak, K Marycz - Marine Drugs, 2020 - mdpi.com

… Our dedicated information section provides allows you to learn more about MDPI. Get Information.
clear. Open AccessReview. Astaxanthin and other Nutrients from Haematococcus
pluvialis—Multifunctional Applications … 5. Astaxanthin as a Valuable Biologically Active Compound …

Save Cite Cited by 33 Related articles All 9 versions 

Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta)

JA Del Campo, H Rodriguez, J Moreno… - Applied microbiology …, 2004 - Springer

… Take part in our 30 minute study now. Download PDF. Original Paper; Published: 20 December
2003. Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta) … 2000).
Astaxanthin is proposed to be active against several types of cancer, lessening the …

Save Cite Cited by 333 Related articles All 17 versions

Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest.

X Qian, C Tan, B Yang, F Wang, Y Ge… - Diseases of the …, 2017 - search.ebscohost.com

… Page 3. Astaxanthin radiosensitize esophageal cancer 3 Fig. 1 ATX inhibited the growth of ESCC
Cells in time- and dose-dependent manner … P < 0.01 Page 5. Astaxanthin radiosensitize
esophageal cancer 5 Fig. 4 ATX enhances radiation induced G2/M arrest in ESCC cells …

Save Cite Cited by 23 Related articles All 3 versions

Developing microencapsulated flaxseed oil containing shrimp (Litopenaeus setiferus) astaxanthin using a pilot scale spray dryer

J Pu, JD Bankston, S Sathivel - Biosystems engineering, 2011 - Elsevier

… Examples of its effectiveness include: the supplementation of astaxanthin effectively suppressed
carcinogenesis in mice urinary bladder tissue (Tanaka et al., 1994), inhibition of tumour growth
in breast cancer (Jyonouchi, Sun, Iijima, & Gross, 2000), and prevention of oxidative …

Save Cite Cited by 88 Related articles All 7 versions

[PDF] researchgate.net

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes

AP Bolin, RC Macedo, DP MarinMP Barros… - Cell biology and …, 2010 - Springer

… 2003), antihypertensive (Hussein et al. 2006a), and anti-tumorogenic properties, especially against
breast, prostate, and liver cancer (Kurihara et al. 2002) … Purified astaxanthin (ASTA) and most
of other chem- icals were purchased from Sigma–Aldrich Chemical Company (St …

Save Cite Cited by 69 Related articles All 13 versions

[HTML] plos.org

[HTML] Improving the stability of astaxanthin by microencapsulation in calcium alginate beads

SF Lin, YC Chen, RN Chen, LC Chen, HO Ho… - PLoS …, 2016 - journals.plos.org

… In addition, the anti-cancer activity of astaxanthin in mammals has been evaluated. Compared
to rats fed with carcinogens only, rats fed with carcinogen but supplemented with astaxanthin
revealed a significant decrease in the incidence of induced colon cancer …

Save Cite Cited by 36 Related articles All 12 versions 

[HTML] jbc.orgFull View

In vitro characterization of astaxanthin biosynthetic enzymes

PD Fraser, Y Miura, N Misawa - Journal of Biological Chemistry, 1997 - ASBMB

… Other diverse biological functions of astaxanthin include an involvement
in cancer prevention ( 8: Tanaka T. Morishita Y. Suzui M. Kojima T.
Okumura A. Mori H. Carcinogenesis. 1994; 15: 15-19 …

Save Cite Cited by 192 Related articles All 9 versions

[PDF] ffhdj.com

Astaxanthin sources: Suitability for human health and nutrition

B Capelli, S Talbott, L Ding - Functional Foods in Health and Disease, 2019 - ffhdj.com

… the superiority of Esterified Astaxanthin (the form present in NAT-AX) over Free Astaxanthin (the
form present in SYN-AX and PH-AX) by demonstrating that esterified AX is superior to Free
Astaxanthin at: • Preventing the formation of skin cancer • Amplifying antioxidant activity …

Save Cite Cited by 19 Related articles All 6 versions 

[HTML] mdpi.com

Astaxanthin prevents human papillomavirus L1 protein binding in human sperm membranes

G Donà, A Andrisani, E Tibaldi, AM Brunati… - Marine drugs, 2018 - mdpi.com

… Abstract. Astaxanthin (Asta), red pigment of the carotenoid family, is known for its
anti-oxidant, anti-cancer, anti-diabetic, and anti-inflammatory properties. In this study,
we evaluated the effects of Asta on isolated human sperm …

Save Cite Cited by 12 Related articles All 9 versions 

[PDF] researchgate.net

Seaweed carotenoids for cancer therapeutics

M Boominathan, A Mahesh - Handbook of anticancer drugs from marine …, 2015 - Springer

… Astaxanthin, a ketocarotenoid is a potent antioxidant and also has various positive attributes
including anti-inflammatory and anticancer activity … Keywords. Carotenoids Seaweed
Fucoxanthin Cancer β-carotene. Download chapter PDF. 10.1 Introduction …

Save Cite Cited by 22 Related articles All 3 versions

[PDF] researchgate.net

Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells

X Zhang, W Zhao, L Hu, L Zhao, J Huang - Archives of biochemistry and …, 2011 - Elsevier

… Download PDFDownload … Effects of carotenoids on cancer cell growth. K562 leukemia cells were
treated with increasing concentrations (1.0–50 μM) of carotenoids (β-carotene, astaxanthin,
capsanthin, and bixin), and the cell number was examined through the trypan blue dye …

Save Cite Cited by 119 Related articles All 8 versions

Astaxanthin modulation of signaling pathways that regulate autophagy

SH Kim, H Kim - Marine drugs, 2019 - mdpi.com

… p38 activation has been shown to be a key determinant in the response of colon cancer
HCT-116 cells to treatment with 5'-fluorouracil by controlling the balance between apoptosis and
autophagy … 3. The Effect of Astaxanthin on the Signaling Pathways That Regulate Autophagy …

Save Cite Cited by 18 Related articles All 9 versions 

Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis

BS Kamath, BM Srikanta, SM Dharmesh… - European Journal of …, 2008 - Elsevier

… The use of astaxanthin as a nutraceutical and a medicinal ingredient against degenerative disease
such as cancer, for prevention of age-related macular degeneration, inflammation, Helicobacter
pylori infection (Wang et al., 2000) and for enhancement of immune responses …

Save Cite Cited by 149 Related articles All 8 versions

[PDF] mdpi.com

The neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective

S Fakhri, I Yosifova Aneva, MH Farzaei… - Molecules, 2019 - mdpi.com

… Give Feedback. Information. Visit our dedicated information section to learn more
about MDPI. Get Information. clear. Open AccessReview. The Neuroprotective Effects
of Astaxanthin: Therapeutic Targets and Clinical Perspective …

Save Cite Cited by 52 Related articles All 12 versions 

[PDF] psu.edu

Cancer prevention by carotenoids

H Nishino, H Tokuda, Y Satomi, M Masuda… - Pure and Applied …, 1999 - degruyter.com

… It is of interest that not only carotenoids distributed in vegetables and fruits, but also animal
carotenoids, such as astaxanthin, are promising as cancer preventive agents. In the present
study, the cancer preventive potential of phytoene was also confirmed …

Save Cite Cited by 129 Related articles All 16 versions

[PDF] tandfonline.com

Suppressive Effect of Astaxanthin Isolated from the Xanthophyllomyces dendrorhous Mutant on Ethanol-Induced Gastric Mucosal Injury in Rats

JH Kim, SK Choi, SY Choi, HK Kim… - Bioscience …, 2005 - Taylor & Francis

… Carcinogenesis, 15, 15–19 (1994). 14) Tanaka, T., Makita, H., Ohnishi, M., Mori, H., Satoh, K.,
and Hara, A., Chemoprevention of rat oral carcino- genesis by naturally occurring xanthophylls,
astaxanthin and canthaxanthin. Cancer Res., 55, 4059–4064 (1995) …

Save Cite Cited by 51 Related articles All 13 versions

[PDF] iiarjournals.orgFree from Publisher

Effect of astaxanthin supplementation on inflammation and cardiac function in BALB/c mice

R Nakao, OL Nelson, JS Park, BD Mathison… - Anticancer …, 2010 - ar.iiarjournals.org

… Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood
mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro
immunoglobulin production in response to a T-dependent stimulant and antigen. Nutr Cancer …

Save Cite Cited by 77 Related articles All 8 versions

[PDF] mdpi.com

Cancer chemoprevention by carotenoids

T Tanaka, M Shnimizu, H Moriwaki - Molecules, 2012 - mdpi.com

… zeaxanthin, β-cryptoxanthin, fucoxanthin, canthaxanthin and astaxanthin, have been proven
to have anti-carcinogenic activity in several tissues, although high doses of β-carotene failed
to exhibit chemopreventive activity in clinical trials. In this review, cancer prevention using …

Save Cite Cited by 533 Related articles All 13 versions 

[PDF] tennessee.edu

Astaxanthin: a comparative case of synthetic vs. natural production

KD Nguyen - 2013 - trace.tennessee.edu

… Bioresour Technol 2005;96:373–8. Palozza, P., Torelli, C., Boninsegna, A., Simone, R.
et al., Growth-‐inhibitory effects of the astaxanthin-‐rich alga Haematococcus pluvialis
in human colon cancer cells. Cancer Lett. 2009, 283, 108–117 …

Save Cite Cited by 64 Related articles All 4 versions 

[HTML] sciencedirect.com

[HTML] Cancer prevention by retinoids and carotenoids: independent action on a common target

JS Bertram, AL Vine - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2005 - Elsevier

… PDFDownload. Share. Export … Simultaneous treatment with a retinoid and β-carotene or
astaxanthin resulted in supra-additive Cx43 expression, again indicating separate mechanisms
of gene regulation. Previous article in issue; Next article in issue … 1.1. Cancer prevention …

Save Cite Cited by 162 Related articles All 6 versions

[PDF] tums.ac.ir

Extraction of astaxanthin esters from shrimp waste by chemical and microbial methods

A Khanafari, A Saberi, M Azar, G Vosooghi… - … Health Science & …, 2007 - ijehse.tums.ac.ir

… Astaxanthin's anti- cancer activity might be related to the carotenoid's role in cell communications
at gap junctions, which might be involved with slowing cancer cell growth, the induction of
xenobiotic-metabolizing enzymes or by modulating immune responses against tumor …

Save Cite Cited by 27 Related articles All 7 versions 

Dietary lutein but not astaxanthin or β-carotene increases pim-1 gene expression in murine lymphocytes

JS Park, BP Chew, TS Wong, JX Zhang… - … and cancer, 1999 - Taylor & Francis

… 16. Jyonouchi, H, Zhang, L, and Tomita, Y: Studies of immunomodulating actions of carotenoids.
II. Astaxanthin enhances in vitro antibody pro- duction to T-dependent antigens without facilitating
polyclonal B-cell activation. Nutr Cancer 19, 269–280, 1993. 17 …

Save Cite Cited by 45 Related articles All 10 versions

[HTML] springer.com

[HTML] Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice

T Kochi, M Shimizu, T Sumi, M Kubota, Y Shirakami… - BMC …, 2014 - Springer

… induced colonic preneoplastic lesions in C57/BL/KsJ-db/dbmice. Download PDF. Download
PDF … Astaxanthin, therefore, may be a potential candidate as a chemoprevention agent against
colorectal … with high mortality, such as ischemic heart disease, stroke, and cancer [1]. In …

Save Cite Cited by 19 Related articles All 14 versions

[HTML] springer.com

[HTML] Astaxanthin as a new Raman probe for biosensing of specific subcellular lipidic structures: can we detect lipids in cells under resonance conditions?

K Czamara, A Adamczyk, M Stojak, B Radwan… - Cellular and Molecular …, 2021 - Springer

… Download PDF. Download PDF. Original Article; Open Access; Published: 08 December 2020 …
Astaxanthin (AXT) is a red pigment well known for its potent antioxidant effect … suggest not only
antioxidative but also anti-inflammatory properties, the ability to suppress cancer, and anti …

Save Cite Cited by 7 Related articles All 8 versions

Protective Effects of Haematococcus Astaxanthin on Oxidative Stress in Healthy Smokers

JH Kim, MJ Chang, HD Choi, YK Youn… - Journal of medicinal …, 2011 - liebertpub.com

… Recently, astaxanthin (ASX) (3,3′-dihydroxy-β,β′-carotene-4,4′-dione), a red carotenoid
pigment with no pro-vitamin A activity, has … to have a key role in protection against a wide range
of ailments, such as inflammation, cardiovascular diseases, cancer, and immunological …

Save Cite Cited by 56 Related articles All 5 versions

[PDF] cloudflare-ipfs.com

The protective effects of astaxanthin against cisplatin-induced retinal toxicity

H Fındık, L TumkayaA Yılmaz… - … and ocular toxicology, 2019 - Taylor & Francis

… Astaxanthin (ASTA) is a member of carotenoids family and has been widely used in food industry
as a pigment 23 , 24 … Its potential antioxidative and neuroprotective effect was suggested as
a therapy option for diabetes, cancer, and hepatotoxicity 29–32 …

Save Cite Cited by 13 Related articles All 7 versions

[HTML] nih.gov

Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis

AR RaoR Sarada, MD Shylaja… - Journal of food science …, 2015 - Springer

… Download PDF. Original Article; Published: 05 March 2015 … Nutraceutical and medical applications
of astaxanthin were reported against diseases such as age-related macular degeneration,
inflammation, cancer, Helicobacter pylori infection (Fassett and Combes 2011) …

Save Cite Cited by 36 Related articles All 11 versions

Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia

YH Kim, HK Koh, DS Kim - International immunopharmacology, 2010 - Elsevier

… Currently, some clinical trials involving the blockade or modulation of IL-6 are under way with
the aim of treating lymphoma, myeloma, renal cancer, rheumatoid arthritis, Crohn's disease, and
hematological malignancy [15]. Astaxanthin is a naturally occurring carotenoid pigment …

Save Cite Cited by 77 Related articles All 8 versions

[PDF] mdpi.com

Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells

JH Kim, SW Nam, BW Kim, W Choi, JH Lee… - International journal of …, 2010 - mdpi.com

… metabolic functions in animals, including neuroprotective actions [9–13], enhancement of immune
response [14,15], and protection against diseases such as cancer [16,17] and antral ulcer
[18,19] by scavenging of oxygen radicals. Antioxidant activity of astaxanthin has been …

Save Cite Cited by 38 Related articles All 19 versions 

Astaxanthin stimulates cell-mediated and humoral immune responses in cats

JS Park, BD Mathison, MG Hayek, S Massimino… - Veterinary Immunology …, 2011 - Elsevier

… Immunopathology. Short communication. Astaxanthin stimulates cell-mediated and humoral
immune responses in cats … Abstract. Astaxanthin is a potent antioxidant carotenoid and
may play a role in modulating immune response in cats. Blood …

Save Cite Cited by 63 Related articles All 6 versions

Astaxanthin isomers: Selective distribution and isomerization in aquatic animals

W Yu, J Liu - Aquaculture, 2020 - Elsevier

… AccessGet Access. Elsevier. Aquaculture. Volume 520, 15 April 2020, 734915.
Aquaculture. Review. Astaxanthin isomers: Selective distribution and isomerization
in aquatic animals. Author links open overlay panelWenjieYu a.

Save Cite Cited by 22 Related articles All 2 versions

Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

A Donoso, J GonzálezAA Muñoz, PA González… - Pharmacological …, 2021 - Elsevier

… Pharmacological Research. Review. “Therapeutic uses of natural astaxanthin: An evidence-based
review focused on human clinical trials”. Author links open overlay panelAndreaDonoso a
JavieraGonzález a Andrés AgurtoMuñoz a Pablo A.González c CristianAgurto-Muñoz a b …

Save Cite Cited by 16 Related articles All 5 versions

[PDF] cambridge.org

Effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells

S Lordan, C O'Neill, NM O'Brien - British journal of nutrition, 2008 - cambridge.org

… the most potent antioxidants among the dietary carotenoids and may help lower the risk of chronic
diseases including cancer and heart … The present results also showed that pretreatment with
0·1mM-astaxanthin significantly (P,0·01) protected against 7b-OH-induced apoptosis …

Save Cite Cited by 42 Related articles All 10 versions

[PDF] mdpi.com

Clinical applications of astaxanthin in the treatment of ocular diseases: Emerging insights

G Giannaccare, M Pellegrini, C Senni, F Bernabei… - Marine drugs, 2020 - mdpi.com

… Astaxanthin exhibits either antiapoptotic or proapoptotic effects depending on the
pathological condition. Indeed, astaxanthin has been shown to induce cancer cell
apoptosis through a mitochondrial-dependent pathway [25] …

Save Cite Cited by 24 Related articles All 9 versions 

[HTML] nih.gov

[HTML] The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss

B Nan, X Gu, X Huang - Drug design, development and therapy, 2019 - ncbi.nlm.nih.gov

… These properties confer astaxanthin with anti-inflammatory and immunomodulatory
activities, protective effects against neuronal damage, anti-aging and anti-cancer
activities, and the ability to inhibit cell membrane peroxidation …

Save Cite Cited by 5 Related articles All 6 versions

[PDF] iiarjournals.orgFree from Publisher

Effects of dietary xanthophylls, canthaxanthin and astaxanthin on N-methyl-N-nitrosourea-induced rat mammary carcinogenesis

T Yuri, K Yoshizawa, Y Emoto, Y Kinoshita, M Yuki… - in vivo, 2016 - iv.iiarjournals.org

… Publications: Anticancer Research; Cancer Genomics & Proteomics. More: IIAR; Conferences.
About Us: General Policy; Contact. Visit iiar on Facebook; Follow us on Linkedin. Research
ArticleExperimental Studies. Effects of Dietary Xanthophylls, Canthaxanthin and Astaxanthin …

Save Cite Cited by 9 Related articles All 4 versions

… distribution of astaxanthin in several tissues and plasma lipoproteins in male broiler chickens fed a yeast (Phaffia rhodozyma) with a high concentration of astaxanthin

K Takahashi, M Watanabe, T Takimoto… - British poultry …, 2004 - Taylor & Francis

… & Francis Online], [Web of Science ®], [Google Scholar]; Jyonouchi, H, Sun, S, Iijima, K and Gross,
MD. 2000. Antitumor activity of astaxanthin and its mode of action. Nutrition and Cancer, 36:
59–65. [Taylor & Francis Online], [Web of Science ®], [Google Scholar]; Jyonouchi, H …

Save Cite Cited by 52 Related articles All 10 versions

[PDF] researchgate.net

The effects of astaxanthin on proliferation and differentiation of MG-63 osteosarcoma cells via aryl hydrocarbon receptor (AhR) pathway: A comparison with AhR …

N Montazeri-NajafabadyMH Dabbaghmanesh… - … and cancer, 2020 - Taylor & Francis

… The anticancer features of AST are due to its impression on cellular pathways including apoptosis,
inflammation and cell junction in cancer cells (12). Recently, the oral administration of Astaxanthin
in the experimental periodontitis model was found to decrease the osteoclast …

Save Cite Cited by 4 Related articles All 6 versions

Studies of immunomodulating actions of carotenoids. I. Effects of β‐carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in …

H Jyonouchi, RJ Hill, Y Tomita, RA Good - 1991 - Taylor & Francis

… because astaxanthin, which does not have provitamin A activity, showed more significant effects
in these bioassays and also indicate that such actions of carotenoid demonstrated in this study
may be difficult to explain only by its oxygen- quenching capacity. (Nutr Cancer 16, 93 …

Save Cite Cited by 145 Related articles All 7 versions

Astaxanthin ameliorates experimental diabetes-induced renal oxidative stress and fibronectin by upregulating connexin43 in glomerular mesangial cells and diabetic …

Q Chen, J Tao, G Li, D Zheng, Y Tan, R Li… - European journal of …, 2018 - Elsevier

… Endocrine pharmacology. Astaxanthin ameliorates experimental diabetes-induced renal oxidative
stress and fibronectin by upregulating connexin43 in glomerular mesangial cells and diabetic
mice … Astaxanthin (AST) belongs to xanthophyll carotenoids family …

Save Cite Cited by 15 Related articles All 6 versions

[PDF] tahomaclinic.com

Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture

Y Kozuki, Y Miura, K Yagasaki - Cancer letters, 2000 - Elsevier

… Cancer cells previously cultured with hypoxanthine (HX) and xanthine oxidase (XO) showed
a highly invasive activity. Carotenoids, 5 μM of β-carotene and astaxanthin, suppressed this
reactive oxygen species-potentiated invasive capacity by simultaneously treating AH109A …

Save Cite Cited by 137 Related articles All 11 versions

Apoptotic effect of astaxanthin from white shrimp shells on lung cancer A549 cells

S Tanasawet, W Sukketsiri… - Tropical Journal of …, 2020 - ajol.info

… Revised accepted: 22 August 2020 Abstract Purpose: To investigate the anti-cancer potential
of astaxanthin from Litopenaeus vannamei encapsulated in liposomes (ASX) to treat lung cancer
A549 cells … Astaxanthin altered lung cancer A549 cell morphology …

Save Cite Cited by 1 Related articles All 5 versions 

Formulation and characterization of O/W nanoemulsions encapsulating high concentration of astaxanthin

N Khalid, G Shu, BJ Holland, I Kobayashi… - Food research …, 2017 - Elsevier

… healthy and this food provides important nutritional bioactive ingredients, such as long-chain
polyunsaturated fatty acids (LCPUFA) and astaxanthin (AXT), that … Ishikawa et al., 2015), reduced
oxidative stress (Xu, Zhu, Yin, & Ding, 2015) and reduction in cancer cell proliferation …

Save Cite Cited by 60 Related articles All 7 versions

Research progress on extraction, biological activities and delivery systems of natural astaxanthin

T Zhao, X Yan, L Sun, T Yang, X Hu, Z He, F Liu… - Trends in Food Science …, 2019 - Elsevier

… PDFDownload. Share. Export. Advanced … Trends in Food Science & Technology. Volume 91,
September 2019, Pages 354-361. Trends in Food Science & Technology. Review. Research
progress on extraction, biological activities and delivery systems of natural astaxanthin …

Save Cite Cited by 45 Related articles All 5 versions

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease

FJ Pashkow, DG Watumull, CL Campbell - The American journal of …, 2008 - Elsevier

… Volume 101, Issue 10, Supplement, 22 May 2008, Pages S58-S68. The American Journal of
Cardiology. Astaxanthin: A Novel Potential Treatment for Oxidative Stress and Inflammation in
Cardiovascular Disease … The Xanthophyll Carotenoid Astaxanthin Targets Oxidative Stress …

Save Cite Cited by 451 Related articles All 9 versions

[HTML] hindawi.com

[HTML] Purified Astaxanthin from Haematococcus pluvialis Promotes Tissue Regeneration by Reducing Oxidative Stress and the Secretion of Collagen In Vitro and In …

HY Chou, DL Ma, CH Leung, CC Chiu… - … medicine and cellular …, 2020 - hindawi.com

… UVB (290-320nm) is the most common cause of skin photodamage, including inflammation
responses, the produc- tion of wrinkles, accumulated aging, and skin cancer [6, 7]. UVB provides
the … This study uses purified astaxanthin from H. pluviali, to regenerate damaged skin …

Save Cite Cited by 5 Related articles All 10 versions 

[HTML] jmb.or.kr

Astaxanthin Inhibits -Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways

JH Kim, WB Choi, JH Lee, SJ Jeon… - … of microbiology and …, 2009 - koreascience.or.kr

… has important metabolic functions in animals, including conversion to vitamin A[3], enhancement
Ofimmune response [14, 25], and protection against diseases Such as cancer by scavenging
oxygen radicals [13, 32–34] The antioxidant activity of astaxanthin has been reported …

Save Cite Cited by 73 Related articles All 16 versions 

[PDF] mdpi.com

Rat Glioma cell-based functional characterization of anti-stress and protein Deaggregation activities in the marine carotenoids, Astaxanthin and Fucoxanthin

S Afzal, S Garg, Y Ishida, K Terao, SC KaulR Wadhwa - Marine drugs, 2019 - mdpi.com

… of functional properties of cells have been shown to contribute to several deleterious pathologies
including cancer and neurodegeneration … study, we explored the anti-stress and
differentiation-inducing potential of two marine bioactive carotenoids (astaxanthin and fucoxanthin …

Save Cite Cited by 17 Related articles All 7 versions 

[PDF] greennetwork-events.com

[PDF] The Cytotoxic Effects of Astaxanthin on Breast Cancer Cells

T Naji, S Niazi, PSK Hamedani - Proceedings of the …, 2019 - greennetwork-events.com

… In line with our finding, previous studies have demonstrated cytotoxic and apoptotic effects of
astaxanthin on cancer cells … [11] In vitro antitumor potential of astaxanthin against cancer cells
via mitochondrial mediated apoptosis has been demonstrated in recent studies …

Save Cite Cited by 1 Related articles 

[HTML] mdpi.com

Astaxanthin counteracts vascular calcification in vitro through an early up-regulation of SOD2 based on a transcriptomic approach

CT Chao, HY Yeh, YT Tsai, TH Yuan, MT Liao… - International Journal of …, 2020 - mdpi.com

… Get Information. clear. Open AccessArticle. Astaxanthin Counteracts Vascular Calcification
In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach … 2.
Results. 2.1. Evaluating the Effect of Astaxanthin in the In Vitro VC Model …

Save Cite Cited by 7 Related articles All 7 versions 

[PDF] mdpi.com

Effects of astaxanthin from Litopenaeus vannamei on carrageenan-induced edema and pain behavior in mice

Z Kuedo, A Sangsuriyawong, W Klaypradit… - Molecules, 2016 - mdpi.com

… Significant evidence supports the versatile properties of astaxanthin as a neutraceutical, such
as protective effect from oxidative stress in healthy smokers [17], tumor prevention in breast cancer
[21], oral cancer [61] and colon cancer [22], and cardiovascular disease [62], as well …

Save Cite Cited by 37 Related articles All 7 versions 

In silico molecular docking of astaxanthin and sorafenib with different apoptotic proteins involved in hepatocellular carcinoma

V Suganya, V Anuradha - Biocatalysis and Agricultural Biotechnology, 2019 - Elsevier

… PDFDownload. Share. Export … Hepatocellular carcinoma (HCC) is the most common type of primary
liver cancer … Astaxanthin is a keto carotenoid with pinkish red colour found in various sea foods,
shrimp, salmon, crab and lobster which have major role as anticancer drug …

Save Cite Cited by 7 Related articles All 3 versions

The role of carotenoids in consumer choice and the likely benefits from their inclusion into products for human consumption

R Baker, C Günther - Trends in Food Science & Technology, 2004 - Elsevier

… Astaxanthin's and canthaxanthin's cancer suppressive role (Gradelet et al., 1998) may
also be explained in relation to vitamin A bio-conversion, where vitamin A is important
in cell differentiation control. However, a further explanation …

Save Cite Cited by 136 Related articles All 5 versions

[PDF] tahomaclinic.com

Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages

Y Kishimoto, M Tani, H Uto-Kondo, M Iizuka… - European journal of …, 2010 - Springer

Advertisement. SpringerLink. Search: Search SpringerLink Search. Astaxanthin suppresses
scavenger receptor expression and matrix metalloproteinase activity in macrophages. Download
PDF. Download PDF. Original Contribution; Published: 26 September 2009 …

Save Cite Cited by 99 Related articles All 14 versions

[PDF] researchgate.net

The inhibition of Caco-2 proliferation by astaxanthin from Xanthophyllomyces dendrorhous

K Wayakanon… - Journal of medical …, 2018 - microbiologyresearch.org

… Keywords: Xanthophyllomyces dendrorhous,; astaxanthin,; colon cancer,; proliferation,;
anti-oxidant … Zhang L, Wang H. Multiple mechanisms of anti-cancer effects exerted by astaxanthin.
Mar Drugs. 2015;13:4310–30. doi: http://dx.doi.org/10.3390/md13074310 …

Save Cite Cited by 5 Related articles All 6 versions

Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer

X Liu, T Osawa - Biochemical and biophysical research communications, 2007 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. Biochemical and Biophysical
Research Communications. Volume 357, Issue 1, 25 May 2007, Pages 187-193. Biochemical
and Biophysical Research Communications. Cis astaxanthin and especially 9-cis astaxanthin …

Save Cite Cited by 189 Related articles All 9 versions

Studies of immunomodulating actions of carotenoids. II. astaxanthin enhances in vitro antibody production to T‐dependent antigens without facilitating polyclonal B …

H Jyonouchi, L Zhang, Y Tomita - 1993 - Taylor & Francis

… 4. Jyonouchi, H, Hill, RJ, Tomita, Y, and Good, RA: "Studies of Immunomodulating Actions of
Carotenoids. I. Effects of ß-Carotene and Astaxanthin on Murine Lymphocyte Functions and Cell
Surface Marker Expression in In VitroCulture System." Nutr Cancer 16, 93-105, 1991 …

Save Cite Cited by 103 Related articles All 11 versions

[HTML] nih.gov

[HTML] Lipid profile and glucose changes after supplementation with astaxanthin: a systematic review and meta-analysis of randomized controlled trials

S Ursoniu, A Sahebkar, MC Serban… - Archives of medical …, 2015 - ncbi.nlm.nih.gov

… doi: 10.5114/aoms.2015.50960. PMCID: PMC4424245. PMID: 25995739. Lipid profile and glucose
changes after supplementation with astaxanthin: a systematic review and meta-analysis of
randomized controlled trials … Keywords: astaxanthin, lipids, antioxidants, glucose …

Save Cite Cited by 71 Related articles All 11 versions

[PDF] cyanotech.com

Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice

Y Naito, K Uchiyama, W Aoi, G Hasegawa… - …, 2004 - content.iospress.com

… [22] H. Kurihara, H. Koda, S. Asami, Y. Kiso and T. Tanaka, Contribution of the antioxidative
property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice
treated with restraint stress, Life Sci 70 (2002), 2509–2520 …

Save Cite Cited by 230 Related articles All 13 versions

Improvement of morpho-physiological, ultrastructural and nutritional profiles in wheat seedlings through astaxanthin nanoparticles alleviating the cadmium toxicity

A Zeshan, M AbdullahMF Adil, D Wei… - Journal of Hazardous …, 2022 - Elsevier

… View PDF; Download full issue. Elsevier. Journal of Hazardous Materials. Volume 424, Part C,
15 February 2022, 126511. Journal of Hazardous Materials. Improvement of morpho-physiological,
ultrastructural and nutritional profiles in wheat seedlings through astaxanthin …

Save Cite Cited by 4 All 4 versions

[HTML] mdpi.com

Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway …

CW Lin, CM Yang, CH Yang - Marine Drugs, 2020 - mdpi.com

… As a potent antioxidant and anti-inflammatory agent, astaxanthin has anti-cancer,
anti-diabetic, and immunomodulatory activity [30] as wells as provides protective effects
in cardiovascular and neurodegenerative diseases [38,45] …

Save Cite Cited by 2 Related articles All 9 versions 

Separation, Purification, and Identification of (3S,3′S)-trans-Astaxanthin from Haematococcus pluvialis

W Sun, H Lin, Y Zhai, L Cao, K Leng… - Separation Science and …, 2015 - Taylor & Francis

… Moreover, astaxanthin has anti-cancer properties (13–15) and therapeutic value in cardiovascular
diseases (16, 17) … II. Astaxanthin enhances in vitro antibody production to T-dependent antigens
without facilitating polyclonal B-cell activation. Nutr. Cancer, 19: 269–280 …

Save Cite Cited by 20 Related articles All 2 versions

[HTML] acs.org

Nanotechnology-Abetted Astaxanthin Formulations in Multimodel Therapeutic and Biomedical Applications

Z Jafari, A BighamS Sadeghi… - Journal of medicinal …, 2021 - ACS Publications

… sum of full text article downloads since November 2008 (both PDF and HTML … Astaxanthin (AXT)
is one of the most important fat-soluble carotenoids that have … and diverse therapeutic applications
namely in liver disease, cardiovascular disease, cancer treatment, protection of the …

Save Cite All 4 versions

[PDF] researchgate.net

Anti‐androgenic effect of astaxanthin in LNCaP cells is mediated through the aryl hydrocarbon‐androgen receptors cross talk

N Montazeri‐Najafabady… - Journal of Food …, 2021 - Wiley Online Library

… PDF PDF … Abstract. The aim of this study was to investigate the anti-androgenic effects of
astaxanthin (AST) on human prostatic cancer cell growth, and its impact on androgen
receptor (AR) signaling using prostate cancer (PCa) cell line LNCaP …

Save Cite Cited by 1 Related articles All 5 versions

[PDF] jst.go.jp

Co-solvent selection for supercritical fluid extraction of astaxanthin and other carotenoids from Penaeus monodon waste

SA Radzali, BS Baharin, R OthmanM Markom… - Journal of oleo …, 2014 - jstage.jst.go.jp

… to other carotenoids such as α-carotene, β-carotene, lutein, lycopene, canthax- anthin, and vitamin
E6, 7). Thus, it has been applied as a food colorant and in pharmaceutical products8, 9). Recently,
some studies proved that astaxanthin inhibits the invasion of cancer cells10) …

Save Cite Cited by 50 Related articles All 9 versions

[PDF] rsc.org

Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

PC Bhatt, P Srivastava, P Pandey, W Khan… - RSC advances, 2016 - pubs.rsc.org

… 10010. Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication,
radio labeling, optimization and biological studies† … 3. Results. 3.1. Characterization and
optimization of astaxanthin solid lipid nanoparticles. Optimization …

Save Cite Cited by 47 Related articles All 3 versions

[PDF] astaxanthin.co.nz

Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

J Monroy-Ruiz, MÁ Sevilla, R Carrón… - Pharmacological …, 2011 - Elsevier

… Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters
in spontaneously hypertensive rats … Twelve-week-old SHR were treated for 8 weeks with an
astaxanthin-enriched diet (75 or 200 mg/kg body weight per day) …

Save Cite Cited by 108 Related articles All 7 versions

Astaxanthin: antioxidant effects in chicken embryo fibroblasts

SM Lawlor, NM O'brien - Nutrition Research, 1995 - Elsevier

… xanthine/xanthine oxidase induced lipid peroxidation (22). Also canthaxanthin,
a carotenoid structurally similar to astaxanthin has been shown to be cytotoxic to
several cancer cell lines without affecting normal cells (23). In …

Save Cite Cited by 73 Related articles All 7 versions

Comparison of Extraction Methods for Recovery of Astaxanthin from Haematococcus pluvialis

D Ruen-ngam, A Shotipruk… - Separation Science and …, 2010 - Taylor & Francis

… [Crossref], [Web of Science ®], [Google Scholar]; Jyonouchi , H. ; Sun , S. ; Iijima , K. ; Gross ,
MD ( 2000 ) Antitumor activity of astaxanthin and its mode of action . Nutrition & Cancer , 36 (
1 ): 59 – 65 . [Taylor & Francis Online], [Web of Science ®], [Google Scholar]; Guerin , M …

Save Cite Cited by 76 Related articles All 4 versions

[PDF] wiley.comFull View

Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders

Z Yaqoob, MS Arshad, M Imran, H Munir… - Food Science & …, 2021 - Wiley Online Library

… and vitamin C. The microalga Haematococcus pluvialis is the richest source of astaxanthin
because it has highest dry weight content about 6%. Astaxanthin consumption is associ- ated
with reduced risk for cancer, cardiovascular diseases, and neu- rodegenerative issues …

Save Cite All 3 versions

[PDF] wiley.com

Disodium Disuccinate Astaxanthin (CardaxTM): Antioxidant and Antiinflammatory Cardioprotection

SF Lockwood, GJ Gross - Cardiovascular drug reviews, 2005 - Wiley Online Library

… FIG. 8. Chemical structure of the “racemic” tetrahydrochloride salt dilysinate diester of astaxanthin …
However, transcriptional upregulation of connexin 43 by DDA in cancer chemoprevention studies
suggests an effect on gap junctional intercellular communication …

Save Cite Cited by 48 Related articles All 6 versions

Separation, Purification, and Identification of (3S,3′S)-trans-Astaxanthin from Haematococcus pluvialis

W Sun, H Lin, Y Zhai, L Cao, K Leng… - Separation Science and …, 2015 - Taylor & Francis

… Moreover, astaxanthin has anti-cancer properties (13–15) and therapeutic value in cardiovascular
diseases (16, 17) … II. Astaxanthin enhances in vitro antibody production to T-dependent antigens
without facilitating polyclonal B-cell activation. Nutr. Cancer, 19: 269–280 …

Save Cite Cited by 20 Related articles All 2 versions

[HTML] acs.org

Nanotechnology-Abetted Astaxanthin Formulations in Multimodel Therapeutic and Biomedical Applications

Z Jafari, A BighamS Sadeghi… - Journal of medicinal …, 2021 - ACS Publications

… sum of full text article downloads since November 2008 (both PDF and HTML … Astaxanthin (AXT)
is one of the most important fat-soluble carotenoids that have … and diverse therapeutic applications
namely in liver disease, cardiovascular disease, cancer treatment, protection of the …

Save Cite All 4 versions

[PDF] researchgate.net

Anti‐androgenic effect of astaxanthin in LNCaP cells is mediated through the aryl hydrocarbon‐androgen receptors cross talk

N Montazeri‐Najafabady… - Journal of Food …, 2021 - Wiley Online Library

… PDF PDF … Abstract. The aim of this study was to investigate the anti-androgenic effects of
astaxanthin (AST) on human prostatic cancer cell growth, and its impact on androgen
receptor (AR) signaling using prostate cancer (PCa) cell line LNCaP …

Save Cite Cited by 1 Related articles All 5 versions

[PDF] jst.go.jp

Co-solvent selection for supercritical fluid extraction of astaxanthin and other carotenoids from Penaeus monodon waste

SA Radzali, BS Baharin, R OthmanM Markom… - Journal of oleo …, 2014 - jstage.jst.go.jp

… to other carotenoids such as α-carotene, β-carotene, lutein, lycopene, canthax- anthin, and vitamin
E6, 7). Thus, it has been applied as a food colorant and in pharmaceutical products8, 9). Recently,
some studies proved that astaxanthin inhibits the invasion of cancer cells10) …

Save Cite Cited by 50 Related articles All 9 versions

[PDF] rsc.org

Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

PC Bhatt, P Srivastava, P Pandey, W Khan… - RSC advances, 2016 - pubs.rsc.org

… 10010. Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication,
radio labeling, optimization and biological studies† … 3. Results. 3.1. Characterization and
optimization of astaxanthin solid lipid nanoparticles. Optimization …

Save Cite Cited by 47 Related articles All 3 versions

[PDF] astaxanthin.co.nz

Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

J Monroy-Ruiz, MÁ Sevilla, R Carrón… - Pharmacological …, 2011 - Elsevier

… Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters
in spontaneously hypertensive rats … Twelve-week-old SHR were treated for 8 weeks with an
astaxanthin-enriched diet (75 or 200 mg/kg body weight per day) …

Save Cite Cited by 108 Related articles All 7 versions

Astaxanthin: antioxidant effects in chicken embryo fibroblasts

SM Lawlor, NM O'brien - Nutrition Research, 1995 - Elsevier

… xanthine/xanthine oxidase induced lipid peroxidation (22). Also canthaxanthin,
a carotenoid structurally similar to astaxanthin has been shown to be cytotoxic to
several cancer cell lines without affecting normal cells (23). In …

Save Cite Cited by 73 Related articles All 7 versions

Comparison of Extraction Methods for Recovery of Astaxanthin from Haematococcus pluvialis

D Ruen-ngam, A Shotipruk… - Separation Science and …, 2010 - Taylor & Francis

… [Crossref], [Web of Science ®], [Google Scholar]; Jyonouchi , H. ; Sun , S. ; Iijima , K. ; Gross ,
MD ( 2000 ) Antitumor activity of astaxanthin and its mode of action . Nutrition & Cancer , 36 (
1 ): 59 – 65 . [Taylor & Francis Online], [Web of Science ®], [Google Scholar]; Guerin , M …

Save Cite Cited by 76 Related articles All 4 versions

[PDF] wiley.comFull View

Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders

Z Yaqoob, MS Arshad, M Imran, H Munir… - Food Science & …, 2021 - Wiley Online Library

… and vitamin C. The microalga Haematococcus pluvialis is the richest source of astaxanthin
because it has highest dry weight content about 6%. Astaxanthin consumption is associ- ated
with reduced risk for cancer, cardiovascular diseases, and neu- rodegenerative issues …

Save Cite All 3 versions

[PDF] wiley.com

Disodium Disuccinate Astaxanthin (CardaxTM): Antioxidant and Antiinflammatory Cardioprotection

SF Lockwood, GJ Gross - Cardiovascular drug reviews, 2005 - Wiley Online Library

… FIG. 8. Chemical structure of the “racemic” tetrahydrochloride salt dilysinate diester of astaxanthin …
However, transcriptional upregulation of connexin 43 by DDA in cancer chemoprevention studies
suggests an effect on gap junctional intercellular communication …

Save Cite Cited by 48 Related articles All 6 versions

Production of new carotenoids, astaxanthin glucosides, by Escherichia coli transformants carrying carotenoid biosynthesis genes

A Yokoyama, Y Shizuri, N Misawa - Tetrahedron Letters, 1998 - Elsevier

… Page 4. 3712 metabolic engineering using recombinant DNA techniques is a powerful tool
for the production of new useful fine chemicals. 15) Antioxidation or cancer prevention activities
of these hydrophilic astaxanthin glucosides will be investigated …

Save Cite Cited by 54 Related articles All 6 versions

Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers

S Gradelet, P Astorg, AM Le Bon, R Bergès… - Cancer letters, 1997 - Elsevier

… The possible role of dietary carotenoids in the pre- vention of cancer has been suggested in many
epide- miological studies … 8'-carotenal and astaxanthin are powerful in vivo inducers of the activities
of liver XME in the rat, with an induction profile closely resembling that of the …

Save Cite Cited by 85 Related articles All 6 versions

Astaxanthin Relieves Busulfan-Induced Oxidative Apoptosis in Cultured Human Spermatogonial Stem Cells by Activating the Nrf-2/HO-1 pathway

A Afzali, F AmidiM KorujiH Nazari, MAS Gilani… - Reproductive …, 2021 - Springer

… Download PDF. Download PDF. Reproductive Biology: Original Article; Published: 15 June 2021 …
Many child cancer patients endure anticancer therapy containing alkylating agents before sexual
maturity … study, we aimed to investigate the protective effect of astaxanthin (AST), as …

Save Cite Related articles All 3 versions

Characterization and evaluation of inclusion complexes between astaxanthin esters with different molecular structures and hydroxypropyl-β-cyclodextrin

X Qiao, L Yang, X Hu, Y Cao, Z Li, J Xu, C Xue - Food Hydrocolloids, 2021 - Elsevier

… Download PDFDownload. Share. Export. Advanced … Characterization and
evaluation of inclusion complexes between astaxanthin esters with different
molecular structures and hydroxypropyl-β-cyclodextrin …

Save Cite Cited by 10 Related articles All 3 versions

Antiproliferation and induction of cell death of Phaffia rhodozyma (Xanthophyllomyces dendrorhous) extract fermented by brewer malt waste on breast cancer cells

ITN Teo, CH Chui, JCO Tang… - International …, 2005 - spandidos-publications.com

… Astaxanthin has been shown to have antipro liferative activity on breast cancer and skin cancer
cells. However, the high cost of production, isolation and purification of purified astaxanthin from
natural sources or chemically synthetic methods limit its usage on cancer therapy …

Save Cite Cited by 13 Related articles All 8 versions

Chitosan-caseinate-dextran ternary complex nanoparticles for potential oral delivery of astaxanthin with significantly improved bioactivity

Q HuS Hu, E Fleming, JY LeeY Luo - International journal of biological …, 2020 - Elsevier

… PDFDownload. Share. Export. Advanced … Volume 151, 15 May 2020, Pages 747-756. International
Journal of Biological Macromolecules. Chitosan-caseinate-dextran ternary complex nanoparticles
for potential oral delivery of astaxanthin with significantly improved bioactivity …

Save Cite Cited by 46 Related articles All 5 versions

[PDF] nih.gov

Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level

N Misawa, Y Satomi, K Kondo, A Yokoyama… - Journal of …, 1995 - Am Soc Microbiol

… 1991. Studies of immunomodulating actions of carotenoids. I. Effects of β-carotene and astaxanthin
on murine lymphocyte functions and cell surface marker expres- sion in in vivo culture system.
Nutr. Cancer 16:93–105. 28. Jyonouchi, H., L. Zhang, and Y. Tomita. 1993 …

Save Cite Cited by 466 Related articles All 14 versions

[HTML] mdpi.com

Astaxanthin treatment induces maturation and functional change of myeloid-derived suppressor cells in tumor-bearing mice

SM Jeong, YJ Kim - Antioxidants, 2020 - mdpi.com

… myeloid-derived suppressor cells; astaxanthin; immunosuppression; tumor environment;
differentiation myeloid-derived suppressor cells; astaxanthin; immunosuppression; tumor … substitute
for conventional therapies in the treatment of intractable diseases such as cancer [1]. To …

Save Cite Cited by 6 Related articles All 9 versions 

[PDF] academia.edu

13 The Production and Health Benefits of Astaxanthin

M Olaizola - Marine nutraceuticals and functional foods, 2007 - books.google.com

… 13.4. 8 ANTICANCER ACTIVITY OF ASTAXANTHIN In the mid-1990s, several animal studies
demonstrated that dietary astaxanthin could protect mammals from cancer following exposure
to known carcinogens (eg, urinary bladder, colon, and mouth [126–128]) …

Save Cite Cited by 20 Related articles All 4 versions

Antioxidant properties of astaxanthin produced by cofermentation between Spirulina platensis and recombinant Saccharomyces cerevisiae against mouse …

X Wang, J Ma, X Bai, H Yan, C Qin, D Ren - Food and Bioproducts …, 2019 - Elsevier

… In addition to this, other biological activities of astaxanthin such as anti-cancer,
anti-inflammatory, anti-diabetic, and immunomodulatory activities had been reported
(Hussein et al., 2006; Ohgami et al., 2003; Suzuki et al., 2006) …

Save Cite Cited by 8 Related articles All 3 versions

Cloning and characterization of the astaxanthin biosynthesis gene cluster from the marine bacterium Paracoccus haeundaensis

JH Lee, YT Kim - Gene, 2006 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. Gene. Volume 370, 29 March
2006, Pages 86-95. Gene. Cloning and characterization of the astaxanthin biosynthesis gene
cluster from the marine bacterium Paracoccus haeundaensis☆ …

Save Cite Cited by 52 Related articles All 8 versions

Potato protein-based carriers for enhancing bioavailability of astaxanthin

R Edelman, S Engelberg, L Fahoum… - Food hydrocolloids, 2019 - Elsevier

… PDFDownload. Share. Export. Advanced … AX consumption was associated with reduced risk for
cancer, cardiovascular diseases, neurodegenerative disorders and more. However, our diet is
generally poor of astaxanthin, which is mainly found in certain algae, salmon and crabs …

Save Cite Cited by 32 Related articles All 4 versions

[PDF] isnff-jfb.com

Critical review of encapsulation methods for stabilization and delivery of astaxanthin

N KhalidCJ Barrow - Journal of Food Bioactives, 2018 - isnff-jfb.com

… structure. Liposomes are mostly used to deliver lipophilic drugs, but liposomes have
numerous applications in the fields of gene delivery and cancer therapy. Astaxanthin
can be encapsulated in liposomes as a targeted drug vehicle …

Save Cite Cited by 15 Related articles All 3 versions 

[PDF] mdpi.com

Astaxanthin-Loaded Stealth Lipid Nanoparticles (AST-SSLN) as Potential Carriers for the Treatment of Alzheimer's Disease: Formulation Development and …

D Santonocito, G Raciti, A Campisi, G Sposito… - Nanomaterials, 2021 - mdpi.com

… SSLN was evaluated on primary olfactory ensheathing cells (OECs) and on MCF-7 cell line, used
as cancer cell type … Astaxanthin (AST), Trolox, AAPH (2,2′-azobis(2-methylpropionamidine)
dihydrochloride), stearic acid, and all reagents were purchased from Sigma-Aldrich (St …

Save Cite Cited by 3 Related articles All 7 versions 

Preparative isolation and purification of astaxanthin from the microalga Chlorococcum sp. by high-speed counter-current chromatography

HB LiF Chen - Journal of Chromatography A, 2001 - Elsevier

… PDFDownload. Share. Export. Advanced … Keywords. Astaxanthin. Carotenoids. Antioxidants.
1. Introduction. Numerous epidemiological studies in various populations have shown that the
consumption of substantial amounts of fruits and vegetables reduce the risk of cancer …

Save Cite Cited by 65 Related articles All 9 versions

[PDF] academia.edu

Molecular modeling of non-covalent binding of homochiral (3S, 3′ S)-astaxanthin to matrix metalloproteinase-13 (MMP-13)

Z BikádiE HazaiF Zsila, SF Lockwood - Bioorganic & medicinal chemistry, 2006 - Elsevier

… Download PDFDownload … drugs (ie, active in the derivatized state) 15 under development for
the treatment of ischemia–reperfusion (I/R) injury,16, 17, 18 cardiovascular inflammation, 19
and cancer chemoprevention and chemotherapy.20, 21, 22 Astaxanthin is abundant …

Save Cite Cited by 34 Related articles All 9 versions

Dietary astaxanthin: an excellent carotenoid with multiple health benefits

Y Cao, L Yang, X Qiao, C Xue, J Xu - Critical Reviews in Food …, 2021 - Taylor & Francis

… citations to date. 0. Altmetric. Listen. Review. Dietary astaxanthin: an excellent
carotenoid with multiple health benefits. Yunrui Caoa College of Food … Review. Dietary
astaxanthin: an excellent carotenoid with multiple health benefits …

Save Cite Cited by 2 All 3 versions

[HTML] mdpi.com

Comparison of Different Methods for Extracting the Astaxanthin from Haematococcus pluvialis: Chemical Composition and Biological Activity

Y Tan, Z Ye, M Wang, MF ManzoorRM Aadil, X Tan… - Molecules, 2021 - mdpi.com

… HPMF), ionic liquids (ILs), multi-enzyme (ME), and hydrochloric acid (HCl)) on the chemical
composition and biological activity of astaxanthin (AST) obtained … cells in a dose-dependent
manner, which was ascribed to AST-induced ROS in to inhibit the proliferative of cancer cells …

Save Cite Cited by 1 Related articles All 3 versions 

Beneficial effects and health benefits of Astaxanthin molecules on animal production: A review

SHA Raza, SRZ Naqvi, SA Abdelnour… - Research in Veterinary …, 2021 - Elsevier

Save Cite Cited by 9 Related articles All 4 versions

[PDF] researchgate.net

[PDF] Peculiarities of modification by astaxanthin the radiation-induced damages in the genome of human blood lymphocytes exposed in vitro on different stages of …

DA Kurinnyi, SR Rushkovsky, OM Demchenko… - Cytol …, 2018 - researchgate.net

… 23. Liu, X., Song, M., Gao, Z., Cai, X., Dixon, W., Chen, X., Cao, Y., and Xiao, H., Stereoisomers
of astaxanthin inhibit human colon cancer cell growth by inducing G2/M cell cycle arrest and
apoptosis, J. Agric. Food Chem., 2016, vol. 64, no. 41, pp. 7750–7759. 24 …

Save Cite Cited by 14 Related articles All 9 versions 

HTML] Antioxidant and anti‑inflammatory mechanisms of action of astaxanthin in cardiovascular diseases

CPM Pereira, ACR Souza… - International …, 2021 - spandidos-publications.com

… Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: ) Metrics: Total PDF Downloads:
0 (Spandidos Publications: | PMC Statistics: ) … 8. Zhang L and Wang H: Multiple mechanisms of
anti-cancer effects exerted by astaxanthin. Mar Drugs. 13:4310–4330 …

Save Cite Cited by 12 Related articles All 11 versions

Supercritical fluid extraction of astaxanthin from Haematococcus pluvialis and its antioxidant potential in sunflower oil

L Wang, B Yang, B Yan, X Yao - Innovative Food Science & Emerging …, 2012 - Elsevier

… Volume 13, January 2012, Pages 120-127. Innovative Food Science & Emerging Technologies.
Supercritical fluid extraction of astaxanthin from Haematococcus pluvialis and its antioxidant
potential in sunflower oil … 2.3. Supercritical fluid extraction and astaxanthin analysis …

Save Cite Cited by 88 Related articles All 3 versions

A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo.

BP Chew, JS Park, MW Wong, TS Wong - Anticancer research, 1999 - europepmc.org

… Antitumor activity of astaxanthin and its mode of action … Nutr Cancer, 36(1):59-65, 01 Jan 2000.
Cited by 78 articles | PMID: 10798217. beta-Carotene and canthaxanthin alter the pro-oxidation
and antioxidation balance in rats fed a high-cholesterol and high-fat diet …

Save Cite Cited by 367 Related articles All 7 versions 

Enhanced astaxanthin production in yeast via combined mutagenesis and evolution

G Jiang, Z Yang, Y Wang, M Yao, Y Chen… - Biochemical …, 2020 - Elsevier

… As a natural red pigment, astaxanthin is widely used in animal and fish feed [1]. Astaxanthin has
attracted increasing interests in its pharmacological activities besides the potent antioxidant
capacity, such as anti-inflammatory [[2], [3], [4]] and anti-cancer [5] activity which …

Save Cite Cited by 15 Related articles All 3 versions

[PDF] wiley.com

Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay

PD Fraser, H Shimada, N Misawa - European Journal of …, 1998 - Wiley Online Library

… The enzymes are biological functions of astaxanthin include, an involvement in cancer prevention
(Tanaka et al., 1994), enhancer of immune also bifunctional in their activity, as the
3,3′-hydroxylase en- zymes can introduce hydroxyl groups into the 3,3′ positions on …

Save Cite Cited by 97 Related articles All 5 versions

[PDF] mdpi.com

Recent advances in astaxanthin micro/nanoencapsulation to improve its stability and functionality as a food ingredient

Ó Martínez-Álvarez, MM Calvo, J Gómez-Estaca - Marine Drugs, 2020 - mdpi.com

… Get Information. clear. Open AccessReview. Recent Advances in Astaxanthin Micro/
Nanoencapsulation to Improve Its Stability and Functionality as a Food Ingredient … 1. Astaxanthin:
A Valuable Marine Resource. 1.1. Chemical Structure and Sources of Astaxanthin …

Save Cite Cited by 18 Related articles All 10 versions 

Simultaneous production of astaxanthin and lipids from Chlorella sorokiniana in the presence of reactive oxygen species: a biorefinery approach

R Yadavalli, H Ratnapuram, JR Peasari… - Biomass Conversion …, 2021 - Springer

… Download PDF. Download PDF. Original Article; Published: 12 January 2021 … In the human body,
carotenoids act as antioxidants [1, 2]. As per the Physician Commission for Responsible Medicine,
they have excellent anti-cancer capabilities [3]. Astaxanthin is an …

Save Cite Cited by 7 Related articles

[HTML] frontiersin.org

[HTML] Astaxanthin-producing green microalga Haematococcus pluvialis: from single cell to high value commercial products

M Shah, R Mahfuzur, Y Liang, JJ Cheng… - Frontiers in plant …, 2016 - frontiersin.org

… Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell
to High Value Commercial Products. Md … Astaxanthin has important applications in
the nutraceuticals, cosmetics, food, and aquaculture industries …

Save Cite Cited by 495 Related articles All 12 versions 

[HTML] mdpi.com

Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway

L Sun, N Miyaji, M Yang, EM Mills, S Taniyama… - Nutrients, 2021 - mdpi.com

… Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen
Species via a Mitochondria-Mediated Apoptosis Pathway … Abstract. Astaxanthin (AX) is a
carotenoid that exerts potent antioxidant activity and acts in the lipid bilayer …

Save Cite Cited by 3 Related articles All 13 versions 

Terpene-based natural deep eutectic systems as efficient solvents to recover astaxanthin from brown crab shell residues

LA Rodrigues, CV Pereira, IC Leonardo… - ACS Sustainable …, 2020 - ACS Publications

… Journal Logo. Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents
To Recover Astaxanthin from Brown Crab Shell Residues. Liliana A. Rodrigues Liliana
A. Rodrigues. Instituto de Biologia Experimental e Tecnológica …

Save Cite Cited by 18 Related articles All 2 versions

[HTML] Mitochondrion-permeable antioxidants to treat ROS-burst-mediated acute diseases

ZW Zhang, XC Xu, T Liu, S Yuan - Oxidative Medicine and Cellular …, 2016 - hindawi.com

… inhibiting tumor growth [79]. (i) Astaxanthin prevents cancer initiation by alleviating DNA
oxidative-damage [80, 81] … surveillance [82]. (iii) Astaxanthin prevents cancer cell growth
in cells by boosting immune detection [83, 84]. (iv) Astaxanthin …

Save Cite Cited by 73 Related articles All 12 versions 

[PDF] mdpi.com

Astaxanthin: a potential therapeutic agent in cardiovascular disease

RG FassettJS Coombes - Marine drugs, 2011 - mdpi.com

… Get Information. clear. Open AccessReview. Astaxanthin: A Potential Therapeutic Agent in
Cardiovascular Disease … 4. AstaxanthinAstaxanthin contains two oxygenated groups on each
ring structure (see Figure 1), which is responsible for its enhanced antioxidant features [41] …

Save Cite Cited by 337 Related articles All 21 versions 

[PDF] mdpi.com

Effect of astaxanthin on human sperm capacitation

G Donà, I Kožuh, AM Brunati, A Andrisani, G Ambrosini… - Marine drugs, 2013 - mdpi.com

… Astaxanthin (Asta), a photo-protective red pigment belonging to the carotenoid family,
is recognized as having anti-oxidant, anti-cancer, anti-diabetic and anti-inflammatory
properties and is present in many dietary supplements …

Save Cite Cited by 36 Related articles All 13 versions 

[PDF] mdpi.com

Neuroprotective properties of the marine carotenoid astaxanthin and omega-3 fatty acids, and perspectives for the natural combination of both in krill oil

MP Barros, SC Poppe, EF Bondan - Nutrients, 2014 - mdpi.com

… Information. Visit our dedicated information section to learn more about MDPI. Get Information.
clear. Open AccessReview. Neuroprotective Properties of the Marine Carotenoid Astaxanthin
and Omega-3 Fatty Acids, and Perspectives for the Natural Combination of Both in Krill Oil …

Save Cite Cited by 98 Related articles All 17 versions 

[PDF] wiley.comFull View

Turning a green alga red: engineering astaxanthin biosynthesis by intragenic pseudogene revival in Chlamydomonas reinhardtii

F Perozeni, S CazzanigaT Baier… - Plant biotechnology …, 2020 - Wiley Online Library

Page 1. Turning a green alga red: engineering astaxanthin … Summary The green alga
Chlamydomonas reinhardtii does not synthesize high-value ketocarotenoids like canthaxanthin
and astaxanthin; however, a b-carotene ketolase (CrBKT) can be found in its genome …

Save Cite Cited by 34 Related articles All 13 versions

[PDF] researchgate.net

Bioavailability of all-E-astaxanthin and Z-isomers of astaxanthin in rainbow trout (Oncorhynchus mykiss)

B Bjerkeng, M Følling, S Lagocki, T Storebakken, JJ Olli… - Aquaculture, 1997 - Elsevier

… Aquaculture. Bioavailability of all-E-astaxanthin and Z-isomers of astaxanthin in rainbow
trout (Oncorhynchus mykiss) … Flesh astaxanthin concentrations increased from 1.7 mg
kg −1 in the initial sample to 6–7 mg kg −1 after 31 days. After …

Save Cite Cited by 166 Related articles All 5 versions

[HTML] plos.org

[HTML] Biocompatible astaxanthin as a novel marine-oriented agent for dual chemo-photothermal therapy

VP Nguyen, SW Kim, H Kim, H Kim, KH Seok, MJ Jung… - PloS one, 2017 - journals.plos.org

… (2017) Biocompatible astaxanthin as a novel marine-oriented agent for dual chemo-photothermal
therapy. PLoS ONE 12(4): e0174687. https://doi.org/10.1371/journal.pone.0174687. Editor: Aamir
Ahmad, University of South Alabama Mitchell Cancer Institute, UNITED STATES …

Save Cite Cited by 18 Related articles All 12 versions 

Inhibitory effect of astaxanthin on pancreatic lipase with inhibition kinetics integrating molecular docking simulation

X Du, M Bai, Y Huang, Z Jiang, F Chen, H Ni… - Journal of Functional …, 2018 - Elsevier

… Download PDFDownload … disease preventing activities (Augusti et al., 2012), Among these
activities, the potential antioxidant activity of astaxanthin is most … that antioxidant activity has a
significant role in the protection against oxidation-damages, inflammation, cancer, aging and …

Save Cite Cited by 18 Related articles All 3 versions

[PDF] academia.edu

Effect of dietary astaxanthin against Aeromonas hydrophila infection in common carp, Cyprinus carpio

C Jagruthi, G Yogeshwari, SM Anbazahan… - Fish & shellfish …, 2014 - Elsevier

… Volume 41, Issue 2, December 2014, Pages 674-680. Fish & Shellfish Immunology. Full length
article. Effect of dietary astaxanthin against Aeromonas hydrophila infection in common carp,
Cyprinus carpio … [40]. 2.2. Astaxanthin-supplementation diet formulation …

Save Cite Cited by 69 Related articles All 10 versions

[PDF] mdpi.com

Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and IL-2 secretion in primary cultured lymphocytes in vitro and ex vivo

KH Lin, KC Lin, WJ Lu, PA Thomas… - International journal of …, 2016 - mdpi.com

Effect of Greenhouse Gases Dissolved in Seawater. Next Article in Special Issue Benzyl
Isothiocyanate Inhibits Prostate Cancer Development in … Astaxanthin, a Carotenoid, Stimulates
Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes …

Save Cite Cited by 71 Related articles All 11 versions 

Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats

Y Xue, C Sun, Q Hao, J Cheng - Naunyn-Schmiedeberg's archives of …, 2019 - Springer

SpringerLink. Search: Search SpringerLink Search. Astaxanthin ameliorates cardiomyocyte
apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway
in rats. Download PDF. Download PDF. Original Article; Published: 30 November 2018 …

Save Cite Cited by 27 Related articles All 4 versions

Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence

RK Saini, YS Keum, M Daglia… - Pharmacological research, 2020 - Elsevier

Save Cite Cited by 26 Related articles All 3 versions

[HTML] nih.gov

[HTML] Astaxanthin inhibits proliferation and induces apoptosis and cell cycle arrest of mice H22 hepatoma cells

Y Shao, Y Ni, J Yang, X Lin, J Li… - Medical science monitor …, 2016 - ncbi.nlm.nih.gov

… Astaxanthin (3, 3′-dihydroxy-β, β'-carotene-4, 4′-dione), (ASX), is a red carotenoid extracted
from phaffia yeast and haematococcus algae … Emerging data indicate that ASX may play a role
in therapy for cancers such as breast cancer, prostate cancer, colon cancer, and …

Save Cite Cited by 28 Related articles All 6 versions

[HTML] plos.org

[HTML] Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis

J Li, Y Xia, T Liu, J Wang, W Dai, F Wang, Y Zheng… - PloS one, 2015 - journals.plos.org

… Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK
Pathway-Mediated Inhibition of Autophagy and Apoptosis … Results. Astaxanthin attenuated serum
liver enzymes and pathological damage by reducing the release of inflammatory factors …

Save Cite Cited by 80 Related articles All 9 versions 

Re-assembled oleic acid-protein complexes as nano-vehicles for astaxanthin: Multispectral analysis and molecular docking

Y Liu, L Huang, D Li, Y Wang, Z Chen, C Zou, W Liu… - Food …, 2020 - Elsevier

… Astaxanthin (ASTA) is a lipid-soluble xanthophyll and exists mainly in algae and marine animals
(Ambati, Phang, Ravi, & … has been also reported, such as prevention of cataract, anti-inflammatory
action, maintenance of heart functionality, and reduction of cancer cell proliferation …

Save Cite Cited by 15 Related articles All 3 versions

Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems

M Zare, Z Norouzi Roshan, E Assadpour… - Critical reviews in food …, 2021 - Taylor & Francis

… breast cancer cells (MDA-MB-231). The astaxanthin-AuNPs represented a strong
cytotoxic impact on breast cancer cells so that in treated cells, apoptotic morphology
was detected. On the other side, the biogenic astaxanthin …

Save Cite Cited by 31 Related articles All 5 versions

Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress and the inflammatory response in mice

J Bi, R Cui, Z Li, C Liu, J Zhang - Biomedicine & Pharmacotherapy, 2017 - Elsevier

… Original article. Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress
and the inflammatory response in mice … Keywords. Astaxanthin. Acute lung injury. Inflammatory
response. Oxidative stress. NF-κB P65. Pulmonary apoptosis. 1. Introduction …

Save Cite Cited by 32 Related articles All 4 versions

Antioxidant status and immunity in Atlantic salmon, Salmo salar L., fed semi‐purified diets with and without astaxanthin supplementation

R Christiansen, J Glette, Ø Lie… - Journal of Fish …, 1995 - Wiley Online Library

… II Analysis and examples. British Journal of Cancer 35, 1-35 … Storebakken T., Foss P., Schiedt
K., Austreng E., Liaaen-Jensen S. & Manz U. (1987) Carotenoids in diets for salmonids IV.
Pigmentation of Atlantic salmon with astaxanthinastaxanthin dipalmitate and canthaxanthin …

Save Cite Cited by 153 Related articles All 3 versions

[PDF] mdpi.com

Enhanced biomass and astaxanthin production of Haematococcus pluvialis by a cell transformation strategy with optimized initial biomass density

F Li, M Cai, M Lin, X Huang, J Wang, H Ke, C Wang… - Marine Drugs, 2020 - mdpi.com

… Get Information. clear. Open AccessArticle. Enhanced Biomass and Astaxanthin Production of
Haematococcus pluvialis by a Cell Transformation Strategy with Optimized Initial Biomass Density …
2.2. The Biomass, Astaxanthin Concentration, and Cell Morphology in the Red Stage …

Save Cite Cited by 6 Related articles All 7 versions 

[HTML] nih.gov

[HTML] Astaxanthin prevents against lipopolysaccharide-induced acute lung injury and sepsis via inhibiting activation of MAPK/NF-κB

X Cai, Y Chen, X Xie, D Yao, C Ding… - American journal of …, 2019 - ncbi.nlm.nih.gov

… Associated Data. Supplementary Materials ajtr0011-1884-f8.pdf (1.0M). GUID:
3C1998C8-138F-4EA2-B3FD-4669ECCBFB25. Abstract … Astaxanthin (ASX), a xanthophyll
carotenoid, exerts beneficial effects against oxidation, inflammation, and cancer …

Save Cite Cited by 44 Related articles All 5 versions

Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat

S Gradelet, P Astorg, J Leclerc, J Chevalier… - Xenobiotica, 1996 - Taylor & Francis

… induce aldehyde dehydrogenase class 3 (ALDHS); this enzyme is not increased, or only
marginally, by canthaxanthin and astaxanthin … Introduction Although a recent intervention study
(The Alpha Tocopherol, Beta Carotene Cancer Prevention Study Group 1994) has shown …

Save Cite Cited by 190 Related articles All 7 versions

[PDF] mdpi.com

Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent

EI BahbahS GhozyMS AttiaA NegidaTB Emran… - Marine Drugs, 2021 - mdpi.com

… Visit our dedicated information section to learn more about MDPI. Get Information. clear. Open
AccessReview. Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent …
(This article belongs to the Special Issue Marine Carotenoids in Inflammation and Cancer …

Save Cite Cited by 4 Related articles All 11 versions 

[HTML] hindawi.com

[HTML] Structures of astaxanthin and their consequences for therapeutic application

THP BrotosudarmoL Limantara… - International Journal of …, 2020 - hindawi.com

… 4. Interaction of Astaxanthin with Reactive Species … For example, elevated levels of prooxidants
and various markers of oxidative stress, and cell and tissue damage are linked to the pathogenesis
of cancer, cardiovascular disease, neurode- generative diseases, reproductive …

Save Cite Cited by 29 Related articles All 9 versions 

[PDF] spandidos-publications.com

Effects of astaxanthin on the protection of muscle health

SK WongS Ima‑Nirwana… - Experimental and …, 2020 - spandidos-publications.com

… Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: ) Metrics: Total PDF Downloads:
0 (Spandidos Publications: | PMC Statistics: ) … The nutraceutical applications of astaxanthin
previously reported include anti-inflammatory (16), anti-cancer (17) and anti …

Save Cite Cited by 7 Related articles All 8 versions

[PDF] wiley.comFull View

Preventive effects of astaxanthin on diethylnitrosamine‐induced liver tumorigenesis in C57/BL/KsJ‐db/db obese mice

T Ohno, M Shimizu, Y Shirakami, T Miyazaki… - Hepatology …, 2016 - Wiley Online Library

… PDF PDF … 10 Therefore, antioxidant therapy with astaxanthin may be a promising strategy for
the management of liver steatosis.11 The antioxidant and anti-inflammatory properties of
astaxanthin have also been associated with its beneficial effects in cancer prevention.12 …

Save Cite Cited by 22 Related articles All 7 versions

[PDF] mdpi.com

Free radical scavenging and cellular antioxidant properties of astaxanthin

J Dose, S Matsugo, H Yokokawa, Y Koshida… - International journal of …, 2016 - mdpi.com

… Get Information. clear. Open AccessArticle. Free Radical Scavenging and Cellular
Antioxidant Properties of Astaxanthin. by … Abstract. Astaxanthin is a coloring agent which
is used as a feed additive in aquaculture nutrition. Recently …

Save Cite Cited by 111 Related articles All 14 versions 

[PDF] mdpi.com

In vitro antioxidant, antityrosinase, and cytotoxic activities of astaxanthin from shrimp waste

S Chintong, W Phatvej, U Rerk-Am, Y Waiprib… - Antioxidants, 2019 - mdpi.com

… In vivo study demonstrated multiple biological activities of astaxanthin to preserve skin health
and achieve effective skin cancer chemoprevention [12]. In addition, with respect to safety, no
adverse events were observed with oral astaxanthin supplementation [13] …

Save Cite Cited by 40 Related articles All 8 versions 

Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes

A Kistler, H Liechti, L Pichard, E Wolz, G Oesterhelt… - Archives of …, 2002 - Springer

… Determination of astaxanthin in human plasma … FT138 was a 73-year-old female with metastasis
of a rectum cancer; FT145 was a 78-year-old female with metastasis of a colic adenocarcinoma;
FT154 was a 61-year-old male with metas- tasis of a rectum cancer; FT167 was a 57 …

Save Cite Cited by 129 Related articles All 13 versions

[PDF] researchgate.net

Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury in rats

H TurkezF Geyikoglu… - Toxicology and Industrial …, 2013 - journals.sagepub.com

… Download article citation data for: Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-
p-dioxin-induced liver injury in rats. Hasan Turkez, Fatime Geyikoglu, and Mokhtar I Yousef.
Toxicology and Industrial Health 2012 29:7, 591-599. Download Citation …

Save Cite Cited by 41 Related articles All 9 versions

Optimization of microwave-assisted extraction of astaxanthin from Haematococcus pluvialis by response surface methodology and antioxidant activities of the extracts

L Zhao, G Chen, G Zhao, X Hu - Separation Science and …, 2009 - Taylor & Francis

… There also exits an inverse relationship between the consumption of foods containing carotenoids
and the risk of lung, intestinal, skin, and bladder cancer (19,20). The antioxidant activity of
astaxanthin was 10 times stronger than that of other carotenoids, namely, zeaxanthin …

Save Cite Cited by 45 Related articles All 3 versions

Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: recent advances and future directions

MX Chang, F Xiong - Molecules, 2020 - mdpi.com

… 12]. However due to the early scare report, which showed that petrochemicals for
astaxanthin synthesis could cause cancer, only the astaxanthin made from algal and
yeast is approved for human consumption [17,18]. Synthetic …

Save Cite Cited by 20 Related articles All 10 versions 

[HTML] mdpi.com

Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U937: SHP-1 as a novel biological target

L Speranza, M Pesce, A Patruno, S Franceschelli… - Marine drugs, 2012 - mdpi.com

… Get Information. clear. Open AccessArticle. Astaxanthin Treatment Reduced Oxidative Induced
Pro-Inflammatory Cytokines Secretion in U937: SHP-1 as a Novel Biological Target … Table 1.
Effect of astaxanthin (ASTA) upon cell viability evaluated by MTT assay …

Save Cite Cited by 111 Related articles All 16 versions 

[PDF] researchgate.net

Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells

M Hosokawa, M Kudo, H Maeda, H Kohno… - … et Biophysica Acta (BBA …, 2004 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier … In the present study, we
demonstrate for the first time that fucoxanthin, not β-carotene or astaxanthin, reduces the
viability of colon cancer cells and induces apoptosis in colon cancer cells …

Save Cite Cited by 415 Related articles All 7 versions

[PDF] jst.go.jp

Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats

Y Okazaki, S Okada, S Toyokuni - Journal of clinical biochemistry …, 2017 - jstage.jst.go.jp

… Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin
and astaxanthin esters from the green alga Haematococcus pluvialis. J Agric Food Chem
2013; 61: 3842–3851. 26 Tanaka T, Kawamori T, Ohnishi M, et al …

Save Cite Cited by 9 Related articles All 8 versions

Vitamin A status and metabolism of cutaneous polyamines in the hairless mouse after UV irradiation: action of beta-carotene and astaxanthin.

N Savoure, G Briand, MC Amory-Touz… - … journal for vitamin …, 1995 - europepmc.org

… Am J Cancer Res, 7(4):740-769, 01 Apr 2017. Cited by: 15 articles | PMID: 28469951 |
PMCID: PMC5411786. Review Free to read … Review. The present perspective of astaxanthin
with reference to biosynthesis and pharmacological importance …

Save Cite Cited by 66 Related articles All 5 versions 

[HTML] spandidos-publications.com

[HTML] Astaxanthin reduces type 2 diabetic‑associated cognitive decline in rats via activation of PI3K/Akt and attenuation of oxidative stress

X Li, Z Qi, L Zhao, Z Yu - Molecular medicine reports, 2016 - spandidos-publications.com

… Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: ). Cited By (CrossRef):
0 citations … SM, Sankar KU, Sarada R and Ravishankar GA: Effective inhibition of skin cancer,
tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters …

Save Cite Cited by 26 Related articles All 6 versions

[PDF] tahomaclinic.com

Evaluation of the protective effects of all-trans-astaxanthin on canine osteosarcoma cell lines

JJ Wakshlag, CA Balkman, SK Morgan… - American journal of …, 2010 - Am Vet Med Assoc

… Discussion. In cell culture models of prostate and breast cancerastaxanthin treatment reportedly
has antiproliferative properties … Chemoprevention of rat oral carcinogenesis by naturally occurring
xanthophylls, astaxanthin and canthaxanthin. Cancer Res 1995;55:4059–4064 …

Save Cite Cited by 16 Related articles All 8 versions

[PDF] aau.dk

[PDF] Research trends in the dominating microalgal pigments, β-carotene, astaxanthin, and phycocyanin used in feed, in foods, and in health applications

NT Eriksen - Journal of Nutrition & Food Sciences, 2016 - vbn.aau.dk

… org/open-access/research-trends-in-the-dominating-microalgal-pigments-carotene-
astaxanthin-and-phycocyanin-used-in-feed-in-foods-and-in-healthappl-2155-9600-1000507.
pdf … Astaxanthin may be used against eg inflammation, cancer, neurogenerative diseases and …

Save Cite Cited by 25 Related articles All 4 versions 

[PDF] researchgate.net

A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions

RM Clark, L Yao, L She, HC Furr - Lipids, 2000 - Wiley Online Library

… Chem. 63, 141–146. 16. Chew, BP, Park, JS, Wong, MW, and Wong, TS (1999) A
Comparison of the Anticancer Activities of Dietary Beta- Carotene, Canthaxanthin and
Astaxanthin in Mice in vivo, Anti- cancer Res. 19, 1849–1853. 17 …

Save Cite Cited by 125 Related articles All 9 versions

Astaxanthin conjugated polypyrrole nanoparticles as a multimodal agent for photo-based therapy and imaging

S BharathirajaP Manivasagan, YO Oh… - International journal of …, 2017 - Elsevier

… Astaxanthin (astx), bovine serum albumin (BSA), pyrrole monomer, dimethyl sulfoxide (DMSO),
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC), N-hydrox −ysuccinimide
(NHS … MDA-MB-231 human breast cancer cells were used as a model cancer cell line …

Save Cite Cited by 18 Related articles A

Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark

PF Ip, F Chen - Process Biochemistry, 2005 - Elsevier

… Download PDFDownload … Google Scholar. [9] H. Nishino, H. Tokuda, Y. Satomi, M. Masuda, P.
Bu, M. Onozuka, et al.Cancer prevention by … 2273-2278. Google Scholar. [10] MN Lyons, NM
O'BrienModulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells …

Save Cite Cited by 257 Related articles All 9 versions

[PDF] researchgate.net

Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress‐dependent neuronal death

V Castelli, F Melani, C FerriM d'Angelo… - Journal of cellular …, 2020 - Wiley Online Library

… Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on
oxidative stress-dependent neuronal death … Department of Biology, Sbarro Institute for Cancer
Research and Molecular Medicine and Center for Biotechnology, Temple … PDF PDF …

Save Cite Cited by 8 Related articles All 5 versions

Enhanced production of free trans-astaxanthin by oxidative stress in the cultures of the green microalga Chlorococcum sp

RYN Ma, F Chen - Process Biochemistry, 2001 - Elsevier

… Astaxanthin has a number of important metabolic functions including enhancement of immune
responses and protection against diseases such as cancer by scavenging oxygen free radicals
[1]. Astaxanthin is widely used as a pigment additive in the aquaculture industry [2] …

Save Cite Cited by 69 Related articles All 7 versions

[HTML] nih.gov

[HTML] Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled …

SI Kumalic, IV Klun, EV Bokal, B Pinter - Radiology and oncology, 2021 - ncbi.nlm.nih.gov

… 41. As one of many antioxidants, ketocarotenoid astaxanthin has the potential to prevent and
treat various diseases, including diabetes, liver and renal diseases, cancer, chronic inflammatory
diseases, cardiovascular diseases, eye and skin diseases, metabolic syndrome …

Save Cite Cited by 2 Related articles All 10 versions

Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress

X Lin, Y Zhao, S Li - European journal of pharmacology, 2017 - Elsevier

… Astaxanthin (AST, 3, 3′-dihydroxy-β, β,-carotene-4, 4′-dione) belongs to the family of
xanthophylls, the oxygenated … have been associated with AST supplementation, including
immunomodulation, prevention and treatment of cardiovascular diseases and cancer (Chew …

Save Cite Cited by 37 Related articles All 7 versions

[HTML] springer.com

[HTML] Astaxanthin uptake in domestic dogs and cats

JS Park, HW Kim, BD Mathison, MG Hayek… - Nutrition & …, 2010 - Springer

… Astaxanthin uptake in domestic dogs and cats. Download PDF. Download PDF. Research; Open
Access; … 11] immune responses, in inhibiting mammary [12] and bladder [13] cancer growth, and …
As an antioxidant, astaxanthin has been shown to possess relatively higher activity as …

Save Cite Cited by 40 Related articles All 23 versions

[HTML] nih.gov

[HTML] Potential antioxidant and wound healing effect of nano-liposol with high loading amount of astaxanthin

H Oh, JS Lee, D Sung, JM Lim… - International Journal of …, 2020 - ncbi.nlm.nih.gov

… C, Huang H, et al. Astaxanthin reduces MMP expressions, suppresses cancer cell
migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma.
J Funct Foods. 2017;31:20–31. doi:10.1016/j.jff.2017.01 …

Save Cite Cited by 4 Related articles All 8 versions

Functional analysis of combinations in astaxanthin biosynthesis genes fromParacoccus haeundaensis

JH Lee, YB Seo, SY Jeong, SW Nam… - Biotechnology and …, 2007 - Springer

… Cancer Inst. 87: 1767-1776. 5. Kurihara, H., H. Koda, S. Asami, Y. Kiso, and T. Tanaka (2002)
Contribution of the antioxidative pro- perty of astaxanthin to its protective effect on the promotion
of cancer metastasis in mice treated with restraint stress. Life Sci. 70: 2509-2520 …

Save Cite Cited by 27 Related articles All 9 versions

[HTML] nih.gov

[HTML] Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis

R Yamagishi, M Aihara - Molecular vision, 2014 - ncbi.nlm.nih.gov

… Anticancer Res. 1999;19(3A):1849–53. [PubMed] [Google Scholar]. 13. Jyonouchi
H, Sun S, Iijima K, Gross MD. Antitumor activity of astaxanthin and its mode of action.
Nutr Cancer. 2000;36:59–65. [PubMed] [Google Scholar]. 14 …

Save Cite Cited by 42 Related articles All 9 versions

[PDF] jst.go.jp

Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat

DH Lee, YJ Lee, KH Kwon - Journal of clinical biochemistry and …, 2010 - jstage.jst.go.jp

… in normal C57B1/6 mice. J. Nutr., 124, 475–484, 1994. [9] Jyonouchi, H., Sun, S.,
Iijima, K., and Gross, MD: Anti- tumor activity of astaxanthin and its mode of action.
Nutr. Cancer, 36, 59–65, 2000. [10] Ohgami, K., Shiratori, K …

Save Cite Cited by 82 Related articles All 13 versions

Micro-pixe analysis in invasive ductal carcinoma tissues after treatment of astaxanthin

S Safaverdi, F ROUSHANI, RM LAMEEI… - 2009 - sid.ir

… Table 1. Comparison of elemental concentrations (ng/cm2) for healthy, cancerous and treated
cancer with astaxanthin breast tissues … John E. Dore (2003) Astaxanthin and cancer chemopre-
vention, Phytopharmaceuticals in Cancer Chemopreven- tion, CRC Press, 555-574 …

Save Cite Cited by 3 Related articles All 8 versions 

[PDF] mdpi.com

Novel insights into the biotechnological production of Haematococcus pluvialis-derived astaxanthin: Advances and key challenges to allow its industrial use as novel …

S Jannel, Y Caro, M Bermudes, T Petit - Journal of Marine Science and …, 2020 - mdpi.com

… Get Information. clear. Open AccessReview. Novel Insights into the Biotechnological Production
of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its
Industrial Use as Novel Food Ingredient … 2. Astaxanthin. 2.1. Biochemistry …

Save Cite Cited by 20 Related articles All 12 versions 

Assessment and comparison of in vitro immunoregulatory activity of three astaxanthin stereoisomers

W Sun, L Xing, H Lin, K Leng, Y Zhai, X Liu - Journal of Ocean University …, 2016 - Springer

… 2013. Effective inhibition of skin cancer, tyrosinase, and antioxidative properties
by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis.
Journal of Agricultural and Food Chemistry, 61: 3842-3851 …

Save Cite Cited by 18 Related articles All 6 versions

Biocompatible liquid-type carbon nanodots (C-paints) as light delivery materials for cell growth and astaxanthin induction of Haematococcus pluvialis

SA Choi, Y Jeong, J Lee, YH Huh, SH Choi… - Materials Science and …, 2020 - Elsevier

… Notably, the results from this study are an essential approach to improve astaxanthin production,
which can be used in various applications because of its therapeutic effects such as cancer
prevention, anti-inflammation, immune stimulation, and treatment of muscle-soreness …

Save Cite Cited by 8 Related articles All 7 versions

Preparation and characterization of glycosylated protein nanoparticles for astaxanthin mitochondria targeting delivery

Y Chen, S Tie, X Zhang, L Zhang, M Tan - Food & Function, 2021 - pubs.rsc.org

… Astaxanthin (ASX) belongs to the xanthophyll class of carotenoids, and is mainly found in algae,
yeast, trout, red seabream, and crustaceans … 19 Mitochondrial dysfunction is closely related to
the occurrence of many diseases, such as cancer, diabetes, and Parkinson's disease …

Save Cite All 3 versions

[HTML] nih.gov

[HTML] Astaxanthin improves cognitive deficits from oxidative stress, nitric oxide synthase and inflammation through upregulation of PI3K/Akt in diabetes rat

L Xu, J Zhu, W Yin, X Ding - International journal of clinical and …, 2015 - ncbi.nlm.nih.gov

… 10 mg/kg)-treated group; DM + AST (20), astaxanthin (20 mg/kg)-treated group; DM + AST (40),
astaxanthin (40 mg/kg … involving increased myeloid-derived suppressor cell levels, systemic
inflammation and hypoalbuminemia are present in patients with anaplastic thyroid cancer …

Save Cite Cited by 59 Related articles All 3 versions

[PDF] researchgate.net

Supplementing with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and-12 expression: a …

HS Yoon, HH Cho, S ChoSR Lee, MH Shin… - Journal of medicinal …, 2014 - liebertpub.com

… 17, No. 7 Full CommunicationsFull Access. Supplementing with Dietary Astaxanthin Combined
with Collagen Hydrolysate Improves Facial Elasticity and Decreases Matrix Metalloproteinase-
1 and -12 Expression: A Comparative Study with Placebo …

Save Cite Cited by 52 Related articles All 8 versions

[HTML] biomedcentral.com

[HTML] Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects

J Gu, Y Chen, L Tong, X Wang… - Journal of …, 2020 - jnanobiotechnology.biomedcentral …

Ototoxicity is one of the major side effects of platinum-based chemotherapy, especially cisplatin
therapy. To date, no FDA approved agents to alleviate or prevent this ototoxicity are available.
However, ototoxicity is generally believed to be produced by excessive generation of reactive …

Save Cite Cited by 9 Related articles All 18 versions 

Advances and trends in biotechnological production of natural astaxanthin by Phaffia rhodozyma yeast

CU MussagyJFB PereiraL Dufossé… - Critical Reviews in …, 2021 - Taylor & Francis

… position of astaxanthin molecule in the cell membrane. These peculiar properties make AXT one
of the most potent xanthophylls with several attractive and promising biological properties,
including antioxidant free radical scavenging (Sztretye et al. 2019), reducing cancer risk …

Save Cite Cited by 1 All 5 versions

[HTML] frontiersin.org

[HTML] Dual-function analysis of astaxanthin on golden pompano (Trachinotus ovatus) and its role in the regulation of gastrointestinal immunity and retinal …

J Niu, W Zhao, DQ Lu, JJ Xie, XS He, HH Fang… - Frontiers in …, 2020 - frontiersin.org

… Dual-Function Analysis of Astaxanthin on Golden Pompano (Trachinotus ovatus) and Its Role
in the Regulation of Gastrointestinal Immunity and Retinal Mitochondrial Dysfunction Under
Hypoxia Conditions … HPLC Conditions for Astaxanthin Analysis …

Save Cite Cited by 1 Related articles All 6 versions 

Understanding response surface optimisation to the modeling of Astaxanthin extraction from a novel strain Thraustochytrium sp. S7

D Singh, A Gupta, SL Wilkens, AS Mathur, DK Tuli… - Algal research, 2015 - Elsevier

… Volume 11, September 2015, Pages 113-120. Algal Research. Understanding response surface
optimisation to the modeling of Astaxanthin extraction from a novel strain Thraustochytrium sp.
S7 … 2.4. Study of growth kinetics, lipid, fatty acid and astaxanthin production …

Save Cite Cited by 27 Related articles All 7 versions

Reprogramming microorganisms for the biosynthesis of astaxanthin via metabolic engineering

X Wan, XR ZhouG Moncalian, L Su, WC Chen… - Progress in Lipid …, 2021 - Elsevier

Save Cite Cited by 8 Related articles All 5 versions

[PDF] the-best-supplements.com

[PDF] Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential

P Kidd - Altern Med Rev, 2011 - the-best-supplements.com

… investi- gated in a small double-blind trial that was pub- lished without peer review.26 Subjects
(ages 40-60 years; n=19), with no diagnosis of cardiovascular disease, kidney disease, diabetes,
or cancer, received three softgel capsules daily supplying either astaxanthin at 12 …

Save Cite Cited by 324 Related articles All 9 versions 

[HTML] hindawi.com

[HTML] A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma

HY Haung, YC Wang, YC Cheng, W Kang… - … medicine and cellular …, 2020 - hindawi.com

… Astaxanthin (AST) is a kind of xanthophyll carotenoid, which commonly occurs in natural seafood
creatures, such as salmon … cardiovascular disease treatment, antibacte- rial property, macular
degeneration improvement, anti- inflammatory activity, and certain cancer inhibition [4 …

Save Cite Cited by 4 Related articles All 6 versions 

[HTML] biomedcentral.com

[HTML] Efficient heterologous expression of an alkaline lipase and its application in hydrolytic production of free astaxanthin

J Huang, Z Yang, R Zhu, X Qian… - Biotechnology …, 2018 - biotechnologyforbiofuels …

Astaxanthin, a naturally occurring carotenoid pigment molecule, displays strong antioxidant,
anti-cancer, and immunity-enhancing properties, and is often utilized in food, biomedical, cosmetic,
and other industries. Free astaxanthin has better solubility than astaxanthin esters (Ast …

Save Cite Cited by 6 Related articles All 15 versions 

[HTML] sciencedirect.com

[HTML] Microalgae in modern cancer therapy: Current knowledge

ME Abd El-Hack, S AbdelnourM Alagawany… - Biomedicine & …, 2019 - Elsevier

Save Cite Cited by 74 Related articles All 5 versions

Physicochemical properties of whey-protein-stabilized astaxanthin nanodispersion and its transport via a Caco-2 monolayer

X Shen, C Zhao, J Lu, M Guo - Journal of agricultural and food …, 2018 - ACS Publications

… Physicochemical Properties of Whey-Protein-Stabilized Astaxanthin Nanodispersion and Its
Transport via a Caco-2 Monolayer … Article Views are the COUNTER-compliant sum of full text
article downloads since November 2008 (both PDF and HTML) across all institutions and …

Save Cite Cited by 26 Related articles All 4 versions

Astaxanthin Induction in Microalga H. pluvialis With Flat Panel Airlift Photobioreactors Under Indoor and Outdoor Conditions

W Poonkum, S Powtongsook… - Preparative Biochemistry …, 2015 - Taylor & Francis

… It also has the ability to protect cell membranes from damage by free radicals, damage that causes
cancer. [ 7 ] Haematococcus pluvialis was reported to be one of the best natural sources of
astaxanthin, as it may accumulate more than 3% astaxanthin by weight …

Save Cite Cited by 29 Related articles All 6 versions

[PDF] researchgate.net

mPEG-carboxymethyl astaxanthin monoester: A novel hydrophilic astaxanthin with increased water solubility and bioavailability

L Yang, X Qiao, H Nan, Y Cao, J Xu, C Xue - LWT, 2021 - Elsevier

… mPEG-carboxymethyl astaxanthin monoester: A novel hydrophilic astaxanthin with increased
water solubility and bioavailability … The results show that mPC-Asta greatly enhances water
solubility and bioavailability of astaxanthin. Previous article in issue; Next article in issue …

Save Cite Related articles All 4 versions

[PDF] mdpi.com

Astaxanthin from Haematococcus pluvialis prevents oxidative stress on human endothelial cells without toxicity

P Régnier, J Bastias, V Rodriguez-Ruiz… - Marine drugs, 2015 - mdpi.com

… Get Information. clear. Open AccessArticle. Astaxanthin from Haematococcus pluvialis Prevents
Oxidative Stress on Human Endothelial Cells without Toxicity … 2.1. Physicochemical
Characterization. 2.1.1. Astaxanthin Identification and Measurements by Spectrophotometry …

Save Cite Cited by 98 Related articles All 17 versio

HTML] Extraction of astaxanthin from microalga Haematococcus pluvialis in red phase by using generally recognized as safe solvents and accelerated extraction

A Molino, J Rimauro, P Casella, A Cerbone… - Journal of …, 2018 - Elsevier

… Download PDFDownload … studies showed its anti-inflammatory, cardioprotective, neuroprotective,
gastroprotective, nephroprotective, anti-diabetic, anti-cancer, antiasthmatic and … For these reasons,
astaxanthin is also currently used in the prevention and control of many …

Save Cite Cited by 89 Related articles All 8 versions

[PDF] jst.go.jpFull View

Effects of astaxanthin in obese mice fed a high-fat diet

M Ikeuchi, T Koyama, J Takahashi… - Bioscience …, 2007 - academic.oup.com

… It has many highly potent pharmaco- logical effects, including antioxidant,4–6) anti-tumor and
anti-cancer,7) anti-diabetic,8) and anti-inflammation ac- tivities.9,10) The chronic effects of
astaxanthin as an anti-obesity agent, However, have not been demonstrated …

Save Cite Cited by 215 Related articles All 17 versions

Hydrophilic astaxanthin: PEGylated astaxanthin fights diabetes by enhancing the solubility and oral absorbability

Y Liu, L Yang, Y Guo, T Zhang, X Qiao… - Journal of agricultural …, 2020 - ACS Publications

… Journal Logo. Hydrophilic Astaxanthin: PEGylated Astaxanthin Fights Diabetes by
Enhancing the Solubility and Oral Absorbability. Yanjun Liu Yanjun Liu. College
of Food Science and Engineering, Ocean University of China …

Save Cite Cited by 8 Related articles All 3 versions

[HTML] oup.com

Astaxanthin enhances the longevity of Saccharomyces cerevisiae by decreasing oxidative stress and apoptosis

S Sj, B Veerabhadrappa, S Subramaniyan… - FEMS yeast …, 2019 - academic.oup.com

… 29 June 2018. Accepted: 11 October 2018. Published: 12 October 2018. pdf PDF; Split View; …
Our results suggest that astaxanthin enhances the longevity of yeast S. cerevisiae by … which are
implicated in aging and various pathologies including cancer, and neurodegenerative …

Save Cite Cited by 16 Related articles All 7 versions

[PDF] mdpi.com

Physicochemical properties and cellular uptake of astaxanthin-loaded emulsions

X Shen, T Fang, J Zheng, M Guo - Molecules, 2019 - mdpi.com

… Visit our dedicated information section to learn more about MDPI. Get Information. clear. Open
AccessArticle. Physicochemical Properties and Cellular Uptake of Astaxanthin-Loaded Emulsions …
2. Results and Discussion. 2.1. Characterization of Astaxanthin-Loaded Emulsions …

Save Cite Cited by 17 Related articles All 9 versions 

[HTML] hindawi.com

[HTML] Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging

M SztretyeB DienesM Gönczi, T Czirják… - … medicine and cellular …, 2019 - hindawi.com

… 5.3. Muscle Atrophy Is Ameliorated by Astaxanthin Treatment. Skeletal muscle atrophy can
occur in case of physiological and several pathological conditions such as immobilization,
aging, chronic diseases (eg, heart failure and renal failure), or cancer …

Save Cite Cited by 47 Related articles All 15 versions 

Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease

MF McCarty - Medical hypotheses, 2011 - Elsevier

Save Cite Cited by 34 Related articles All 5 versions

Control of cell proliferation in cancer prevention

H Mori, S Sugie, N Yoshimi, A Hara… - … and Molecular Mechanisms …, 1999 - Elsevier

… that the telomerase activity could be a useful biomarker in association with cell proliferation on
studies for cancer prevention … like protocatechuic acid (PCA) [11]or chlorogenic acid [12],
flavonoids like diosmin or hesperidin [13], carotenoids like astaxanthin or canthaxanthin [14 …

Save Cite Cited by 88 Related articles All 8 versions

[PDF] mdpi.com

Astaxanthin in cardiovascular health and disease

RG FassettJS Coombes - Molecules, 2012 - mdpi.com

… Get Information. clear. Open AccessReview. Astaxanthin in Cardiovascular Health and Disease …
In experimental studies the polar astaxanthin has myocardial preservation effects but this is
yet to be confirmed in human clinical trials [38,39,40]. 4. Astaxanthin …

Save Cite Cited by 169 Related articles All 15 versions 

Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications

KN Singh, S Patil, H Barkate - Journal of cosmetic dermatology, 2020 - Wiley Online Library

… PDF PDF … Share a link. Share on: Email; Facebook; Twitter; Linked In; Reddit; Wechat. Abstract.
Astaxanthin is a naturally occurring ketocarotenoid which has been found to have numerous
biological functions, with its strong antioxidant property being the prominent feature …

Save Cite Cited by 31 Related articles All 3 versions

xtraction of shrimp astaxanthin with flaxseed oil: effects on lipid oxidation and astaxanthin degradation rates

J Pu, PJ Bechtel, S Sathivel - Biosystems engineering, 2010 - Elsevier

… Because of its antioxidant properties, astaxanthin may have a role in the treatment
of chronic diseases such as cardiovascular diseases, cataract development, macular
degeneration, and some types of cancer (Mayne, 1996) …

Save Cite Cited by 82 Related articles All 8 versions

Effect of β, β-carotene, β-echinenone, astaxanthin, fucoxanthin, vitamin A and vitamin E on the biological defense of the sea urchin Pseudocentrotus depressus

T Kawakami, M Tsushima, Y Katabami, M Mine… - Journal of Experimental …, 1998 - Elsevier

… Effect of β,β-carotene, β-echinenone, astaxanthin, fucoxanthin, vitamin A and vitamin
E on the biological defense of the sea urchin Pseudocentrotus depressus … Control,
β,β-Carotene, β-Echinenone, Astaxanthin, Vitamin A, Vitamin E …

Save Cite Cited by 98 Related articles All 6 versions 

Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide‐induced acute cardiomyopathic rat model

SS Kamel, NAA Baky, RM Karkeet… - Clinical and …, 2021 - Wiley Online Library

… doi:10.1155/2019/3849692. 7. Faraone I, Sinisgalli C, Ostuni A, Armentano MF, Carmosino M,
Milella L, Russo D, Labanca F, Khan H. Astaxanthin anti-cancer effects are mediated through
multiple molecular mechanisms: A systematic review. Pharmacol Res. 2020;155:104689 …

Save Cite All 4 versions

[PDF] royalsocietypublishing.orgFull View

Optimization and characterization of poly(lactic-co-glycolic acid) nanoparticles loaded with astaxanthin and evaluation of anti-photodamage effect in vitro

F Hu, W Liu, L Yan, F Kong… - Royal Society open …, 2019 - royalsocietypublishing.org

… or in aquatic animals, such as crabs, salmon and lobsters [1,2]. Furthermore, owing to its numerous
biological activities, such as anti-cancer [3], anti-oxidation [4], anti-inflammation [5], decreasing
the risk of cardiovascular diseases [6] and photodamage [7], astaxanthin is often …

Save Cite Cited by 10 Related articles All 7 versions

[PDF] tahomaclinic.com

Protection against oxidative stress, inflammation, and apoptosis of high-glucose-exposed proximal tubular epithelial cells by astaxanthin

YJ KimYA Kim, T Yokozawa - Journal of agricultural and food …, 2009 - ACS Publications

… Protection against Oxidative Stress, Inflammation, and Apoptosis of High-Glucose-Exposed
Proximal Tubular Epithelial Cells by Astaxanthin … Article Views are the COUNTER-compliant sum
of full text article downloads since November 2008 (both PDF and HTML) across all …

Save Cite Cited by 104 Related articles All 11 versions

[HTML] acs.orgFull View

Chemical Transformation of Astaxanthin from Haematococcus pluvialis Improves Its Antioxidative and Anti-inflammatory Activities

SH Hwang, JM Kim, S Kim, MJ Yoon, KS Park - ACS omega, 2020 - ACS Publications

… Journal Logo. Chemical Transformation of Astaxanthin from Haematococcus pluvialis
Improves Its Antioxidative and Anti-inflammatory Activities. Sung Hyun Hwang Sung
Hyun Hwang. Department of Biological Engineering, College …

Save Cite Cited by 4 Related articles All 5 versions

[PDF] mdpi.com

A Quantitative Analysis Model Established to Determine the Concentration of Each Source in Mixed Astaxanthin from Different Sources

X Du, X Wang, M Bai, S Liu, G Huang, Q Zhang, H Ni… - Molecules, 2020 - mdpi.com

… A Quantitative Analysis Model Established to Determine the Concentration of Each Source in
Mixed Astaxanthin from Different Sources … 2. Results and Discussion. 2.1. Identification of
Astaxanthin from Different Sources Using High-Performance Liquid Chromatography (HPLC) …

Save Cite Cited by 3 Related articles All 7 versions 

Astaxanthin and canthaxanthin are potent antioxidants in a membrane model

P Palozza, NI Krinsky - Archives of biochemistry and biophysics, 1992 - Elsevier

… Nevertheless, our data provide supporting evidence for a potent an- tioxidant activity of both
astaxanthin and canthaxanthin … 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. Bjelke, E. (1975) Znt. J. Cancer
15, 561-565. Peto, R., Doll, RJ, Buckley, JD, and Sporn, MB (1981) Nature 290,201-208 …

Save Cite Cited by 435 Related articles All 8 versions

[HTML] sciencedirect.com

[HTML] Lutein, zeaxanthin and astaxanthin protect against DNA damage in SK-N-SH human neuroblastoma cells induced by reactive nitrogen species

M Santocono, M Zurria, M Berrettini, D Fedeli… - … of Photochemistry and …, 2007 - Elsevier

… can have provitamin A activity [6] and offer important actions (ie lycopene has been associated
with a reduced risk for prostate cancer) [7], [8 … Although astaxanthin has never been isolated from
the human eye, it was included in this study because its structure is very close to that …

Save Cite Cited by 96 Related articles All 6 versions

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury

S FakhriL Dargahi, F Abbaszadeh, M Jorjani - Brain research bulletin, 2018 - Elsevier

… Research report. Astaxanthin attenuates neuroinflammation contributed to the neuropathic
pain and motor dysfunction following compression spinal cord injury … Highlights. • Astaxanthin
(AST) improved sensory-motor performance after compression SCI. • …

Save Cite Cited by 39 Related articles All 4 versions

[PDF] SPC212 Human Mesothelioma Cell Underwent Apoptosis, Oxidative Stress, Morhological Deformation Following Astaxanthin Treatment

S Kacar, TS Sevimli, V Sahinturk - 2021 - researchsquare.com

… doi:10.1016/j.bbagen.2013.05.032 Kim, H.-Y., Kim, Y.-M., & Hong, S. (2019). Astaxanthin
suppresses the metastasis of colon cancer by … (2019). Astaxanthin inhibits hallmarks of cancer
by targeting the PI3K/NF-κΒ/STAT3 signalling axis in oral squamous cell carcinoma models …

Save Cite Cited by 1 

[PDF] academia.edu

Astaxanthin and canthaxanthin (xanthophyll) as supplements in rainbow trout diet: In vivo assessment of residual levels and contributions to human health

P Brizio, A Benedetto, M Righetti… - Journal of agricultural …, 2013 - ACS Publications

… Astaxanthin and Canthaxanthin (Xanthophyll) as Supplements in Rainbow Trout Diet: In Vivo
Assessment of Residual Levels and Contributions to Human … Article Views are the
COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and …

Save Cite Cited by 23 Related articles All 10 versions

Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment

W Diao, W Chen, W Cao, H Yuan, H Ji, T Wang… - … et Biophysica Acta (BBA …, 2019 - Elsevier

… PDFDownload. Share. Export. Advanced. Elsevier … In addition to its antioxidant effects, astaxanthin
has anti-lipid peroxidation, anti-inflammation, anti-diabetic, and anti-cancer activity. In recent
years, it was also found to protect against liver and lung fibrosis [[15], [16], [17]] …

Save Cite Cited by 13 Related articles All 5 versions

[PDF] researchgate.net

Astaxanthin prevented oxidative stress in heart and kidneys of isoproterenol-administered aged rats

MN AlamMM HossainMM Rahman… - Journal of dietary …, 2018 - Taylor & Francis

… The high antioxidant power of astaxanthin has shown beneficial effects on various diseases
related to oxidative stress, such as hypertension, obesity, macular degeneration, and cancer
(Hussein et al., 2005; Ikeuchi et al., 2007; Santocono et al., 2006; Hix et al., 2005; Kurihara …

Save Cite Cited by 40 Related articles All 4 versions

Comparison effect of dietary astaxanthin and β-carotene in the presence and absence of cholesterol supplementation on growth performance, antioxidant capacity …

J Niu, H Wen, CH Li, YJ Liu, LX Tian, X Chen, Z Huang… - Aquaculture, 2014 - Elsevier

… Comparison effect of dietary astaxanthin and β-carotene in the presence and absence of
cholesterol supplementation on growth performance, antioxidant capacity and gene
expression of Penaeus monodon under normoxia and hypoxia condition …

Save Cite Cited by 70 Related articles All 9 versions

[PDF] mdpi.com

Enriched astaxanthin extract from Haematococcus pluvialis augments growth factor secretions to increase cell proliferation and induces MMP1 degradation to …

HY Chou, C Lee, JL Pan, ZH Wen, SH Huang… - International Journal of …, 2016 - mdpi.com

… Enriched Astaxanthin Extract from Haematococcus pluvialis Augments Growth Factor Secretions
to Increase Cell Proliferation and Induces MMP1 … 21. Center for Infectious Disease and Cancer
Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan. *. Authors to whom …

Save Cite Cited by 33 Related articles All 8 versions 

Production of astaxanthin from Haematococcus in open pond by two-stage growth one-step process

BY Zhang, YH Geng, ZK Li, HJ Hu, YG Li - Aquaculture, 2009 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. Aquaculture. Volume 295, Issues
3–4, 16 October 2009, Pages 275-281. Aquaculture. Production of astaxanthin from
Haematococcus in open pond by two-stage growth one-step process …

Save Cite Cited by 115 Related articles All 8 versions

[PDF] archbreastcancer.com

Molecular Simulations Identify Target Receptor Kinases Bound by Astaxanthin to Induce Breast Cancer Cell Apoptosis

M Gardaneh, Z Nayeri, P Akbari… - … of Breast Cancer, 2020 - archbreastcancer.com

… Development of animal models to elucidate interactions between the compound and tumor
microenvironment could be a major step forward towards the inclusion of astaxanthin in cancer
therapy trials … by Astaxanthin to Induce Breast Cancer Cell Apoptosis …

Save Cite Related articles All 7 versions 

[PDF] mdpi.com

Inhibitory Effect of Astaxanthin on Gene Expression Changes in Helicobacter pylori-Infected Human Gastric Epithelial Cells

SH Kim, H Kim - Nutrients, 2021 - mdpi.com

… Keywords: Helicobacter pylori; gastric epithelial cells; astaxanthin; β-catenin; cell
proliferation; gastric cancer Helicobacter pylori; gastric epithelial cells; astaxanthin;
β-catenin; cell proliferation; gastric cancer. 1. Introduction. Gastric …

Save Cite All 7 versions 

Induction of astaxanthin accumulation by nitrogen and magnesium deficiencies in Haematococcus pluvialis

J Fábregas, A Domínguez, DG Álvarez, T Lamela… - Biotechnology …, 1998 - Springer

… deficiency seems to be the most important factor trig- gering the synthesis of astaxanthin in the
cell, the use of both N-deficiency and high light is desirable when max- imal productivity of
astaxanthin is pursued … Nutr Cancer 16:93–105 Kobayashi, M, Kurimura, Y and Tsuji, Y (1997 …

Save Cite Cited by 94 Related articles All 13 versions

Oxidative stress and astaxanthin: The novel supernutrient carotenoid

S Biswal - International Journal of Health & Allied Sciences, 2014 - go.gale.com

… Disodium disuccinate astaxanthin (Cardax): Antioxidant and antiinflammatory cardioprotection.
Cardiovasc Drug Rev 2005;23:199-216. 37. Jyonouchi H, Sun S, Iijima K, Gross MD. Antitumor
activity of astaxanthin and its mode of action. Nutr Cancer 2000;36:59-65. 38 …

Save Cite Cited by 20 Related articles

[PDF] mdpi.com

Pro-oxidant actions of carotenoids in triggering apoptosis of cancer cells: A review of emerging evidence

J Shin, MH Song, JW Oh, YS Keum, RK Saini - Antioxidants, 2020 - mdpi.com

… 20,21]. For example, from an equimolar mixture of astaxanthin, β-carotene, and lutein
(2.5 mM each), astaxanthin has the highest cellular uptake by MCF-7 breast cancer
cells, followed by β-carotene and lutein [22]. As expected …

Save Cite Cited by 35 Related articles All 8 versions 

[PDF] researchgate.net

Antioxidant activity of β‐carotene‐related carotenoids in solution

J Terao - Lipids, 1989 - Wiley Online Library

… PDF PDF … These results suggest that canthaxanthin and astaxanthin are more effective antioxidants
than β‐carotene by stabilizing the trapped radicals. AMVN; 2,2′‐azobis(2,4‐dimethylvaleronitrile);
HPLC; high performance liquid chromatography … Cancer Res. 45, 2369– 2372 …

Save Cite Cited by 658 Related articles All 13 versions

[HTML] tandfonline.comFull View

Protective effects of ginsenoside Rg2 and astaxanthin mixture against UVB-induced DNA damage

YH Chung, SA Jeong, HS Choi, S Ro… - Animal cells and …, 2018 - Taylor & Francis

… Astaxanthin (ASTA), known as red carotenoid pigment, belongs to the xanthophylls class of
carotenoids (Yang et al … metabolic functions in animals, including potent anti-tumoral, anti-oxidant,
anti-inflammatory, neuroprotection, and protection against diseases such as cancer …

Save Cite Cited by 13 Related articles All 9 versions

Enhancing the stability of astaxanthin by encapsulation in poly (l-lactic acid) microspheres using a supercritical anti-solvent process

G Liu, M Hu, Z Zhao, Q Lin, D Wei, Y Jiang - Particuology, 2019 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. Particuology. Volume 44, June
2019, Pages 54-62. Particuology … Because of these strong antioxidant properties, astaxanthin
exhibits a wide range of beneficial health properties: anti-cancer (Zhang & Wang, 2015 …

Save Cite Cited by 15 Related articles All 2 versions

Enhancement of astaxanthin biosynthesis in Haematococcus pluvialis via inhibition of autophagy by 3-methyladenine under high light

X Wang, Y Song, B Liu, W Hang, R Li, H Cui, R Li, X Jia - Algal Research, 2020 - Elsevier

… Download PDFDownload … has multiple applications in food and aquaculture industries, cosmetics,
particularly in healthcare and pharmaceuticals for anti-aging, anti-cancer and prevention of
cardiovascular and diabetes diseases [7,8]. Astaxanthin accumulation has …

Save Cite Cited by 9 Related articles All 3 versions

Rapid baseline separation of enantiomers and a mesoform of all-trans-astaxanthin, 13-cis-astaxanthin, adonirubin, and adonixanthin in standards and commercial …

C Wang, DW Armstrong, CD Chang - Journal of Chromatography A, 2008 - Elsevier

… PDFDownload. Share. Export … These include cardiovascular problems, inflammation, ulcerous
infections, and UV-light damage [1], [2]. Other benefits such as immunomodulating [4] and
anti-cancer properties [5] of astaxanthin have been reported in literature …

Save Cite Cited by 54 Related articles All 9 versions

[PDF] jst.go.jp

Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study

M Katagiri, A Satoh, S Tsuji… - Journal of clinical …, 2011 - jstage.jst.go.jp

… J Nat Prod 2006; 69: 443–449. 3 Kurihara H, Koda H, Asami S, Kiso Y, Tanaka T. Contribution
of the anti- oxidative property of astaxanthin to its protective effect on the promotion of cancer
metastasis in mice treated with restraint stress. Life Sci 2002; 70: 2509–2520 …

Save Cite Cited by 76 Related articles All 13 versions

The simultaneous carrier ability of natural antioxidant of astaxanthin and chemotherapeutic drug of 5-fluorouracil by whey protein of β-lactoglobulin: spectroscopic and …

H Gholami, A Divsalar… - Journal of …, 2021 - Taylor & Francis

… Astaxanthin (ATX) with a molar mass of 596.852 g/mol and the molecular formula C 40 H 52 O
4 is a red lipophilic … New data suggest that ATX may have anticancer efficacy in the treatment of
cancers, including oral cancer, breast cancer, colorectal cancer, leukemia and …

Save Cite Cited by 5 Related articles All 6 versions

Ability of natural astaxanthin from shrimp by-products to attenuate liver oxidative stress in diabetic rats

A Sila, Z Kamoun, Z Ghlissi, M MakniM Nasri… - Pharmacological …, 2015 - Springer

Page 1. Original research article Ability of natural astaxanthin from shrimp by-products
to attenuate liver oxidative stress in diabetic rats Assaâd Sila … 2014 Keywords: Diabetes
Rats Liver Astaxanthin Oxidative stress ABSTRACT Background …

Save Cite Cited by 42 Related articles All 5 versions

[HTML] Reversal of homocysteine-induced neurotoxicity in rat hippocampal neurons by astaxanthin: Evidences for mitochondrial dysfunction and signaling crosstalk

X Wang, W Chen, X Fu, J Ma, M Wang, Y Hou… - Cell death …, 2018 - nature.com

Reversal of homocysteine-induced neurotoxicity in rat hippocampal neurons by
astaxanthin: evidences for mitochondrial dysfunction and signaling crosstalk.
Download PDF. Article; Open Access; Published: 22 October 2018 …

Save Cite Cited by 15 Related articles All 7 versions

Cellular uptake of carotenoid-loaded oil-in-water emulsions in colon carcinoma cells in vitro

HS Ribeiro, JMM Guerrero, K Briviba… - Journal of agricultural …, 2006 - ACS Publications

… Article Views are the COUNTER-compliant sum of full text article downloads since November
2008 (both PDF and HTML) across all … sucrose laurate (L-1695), and polyoxyethylene-20-sorbitan-
monolaurate (Tween 20), on the stability of lycopene and astaxanthin in emulsions …

Save Cite Cited by 104 Related articles All 8 versions

[PDF] jst.go.jp

Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei

S Yang, Q Zhou, L Yang, Y Xue, J Xu… - Journal of oleo …, 2015 - jstage.jst.go.jp

… Recent studies have demonstrated that astaxanthin showed 80% anti-lipid peroxidation activity
in ethanol induced gastric ulcer rats and skin cancer rats4, 5). Other effects of astaxanthin on
human health nutrition, such as anti-aging6), improving lipid metabolism1), anti …

Save Cite Cited by 42 Related articles All 7 versions

[PDF] cyanotech.com

Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin

M Østerlie, B Bjerkeng, S Liaaen-Jensen - The Journal of nutritional …, 2000 - Elsevier

… carotenoids from fruits and vegetables, in particular β,β-carotene, have been associated with
a decreased risk of certain cancer forms and … Astaxanthin (3,3′-dihydroxy-β,β-carotene-4,4′-
dione) is widely distributed in the animal kingdom (in particular, marine seafood such as …

Save Cite Cited by 221 Related articles All 12 versions

Preparation of astaxanthin micelles self-assembled by a mechanochemical method from hydroxypropyl β-cyclodextrin and glyceryl monostearate with enhanced …

W Su, NE Polyakov, W Xu, W Su - International Journal of Pharmaceutics, 2021 - Elsevier

… View PDF; Download full … including diabetes (Sajjad et al., 2017), inflammation (Kishimoto et al.,
2016), immunodeficiency disorders and cancer (Hussein et al … Astaxanthin (AST) is a
xanthophyll-type carotenoid that is mostly found in microorganisms and marine animals (Hussein …

Save Cite Cited by 2 All 4 versions

[PDF] mdpi.com

Astaxanthin Delivery Systems for Skin Application: A Review

SGM Lima, MCLC Freire, VS Oliveira, C Solisio… - Marine Drugs, 2021 - mdpi.com

… several skin health benefits, including antioxidant and anti-aging effects [13,15,16,17,18,19],
protection against UV irradiation [16,20], anti-wrinkle [14,16,21], hydration [21], wound healing
[22,23], anti-cancer properties [17 … 2. Astaxanthin Delivery Systems for Skin Application …

Save Cite Cited by 1 All 10 versions 

Astaxanthin in cardiovascular health and disease: mechanisms of action, therapeutic merits, and knowledge gaps

F Visioli, C Artaria - Food & Function, 2017 - pubs.rsc.org

… 2 because they are derived from the fermentation Saccharomyces cerevisiae (yeast) and
Paracoccus carotinifaciens (Phaffia rhodozyma), therefore containing approximately 30% of
carotenoids other than astaxanthin (see http://ec.europa.eu/food/fs/sc/scan/out111_en.pdf) …

Save Cite Cited by 108 Related articles All 5 versions

[HTML] nih.gov

Optimization of acidic extraction of astaxanthin from Phaffia rhodozyma

H Ni, Q Chen, G He, G Wu, Y Yang - Journal of Zhejiang University …, 2008 - Springer

… Ad- ditionally, other diverse biological functions of astaxanthin have attracted more and more
interest due to its health benefits to human beings in light of its roles in cancer prevention,
enhancement of im- mune response, and serving as a free radical quencher (Fraser et al …

Save Cite Cited by 67 Related articles All 16 versions

Development and Evaluation of Astaxanthin as Nanostructure Lipid Carriers in Topical Delivery

Q Geng, Y Zhao, L Wang, L Xu, X Chen, J Han - AAPS PharmSciTech, 2020 - Springer

… Search SpringerLink Search. Development and Evaluation of Astaxanthin as
Nanostructure Lipid Carriers in Topical Delivery. Download PDF. Download PDF.
Research Article; Published: 11 November 2020. Development and …

Save Cite Cited by 5 Related articles All 4 versions

[PDF] psu.edu

Stabilization of astaxanthin using nanoliposome

JM Yoo, SY Kim, EA Cho, EH Cho, SJ Choi… - KSBB …, 2010 - koreascience.or.kr

… Anticancer Res. 19: 1849-1854. 9. Jyonouchi, H., S. Sun, K. Iijima, and M. Gross (2000) Antitumor
activity of astaxanthin and its mode of action. Nutr. Cancer. 36: 59-65. 10. Marnett, LJ (1987)
Peroxyl free astaxanthin radicals: potential mediators of tumor initiation and promotion …

Save Cite Cited by 13 Related articles All 6 versions 

Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms

SR Kumar, M Hosokawa, K Miyashita - Marine drugs, 2013 - mdpi.com

… In a separate study, Hosokawa et al. [27] compared the effects of fucoxanthin and other
carotenoids such as β-carotene and astaxanthin on colon cancer cell lines (Caco-2, HT-29, and
DLD-1). Cell viability was found to be significantly decreased with fucoxanthin as compared …

Save Cite Cited by 197 Related articles All 13 versions 

[HTML] hindawi.com

[HTML] Oxidative stress regulation on endothelial cells by hydrophilic astaxanthin complex: Chemical, biological, and molecular antioxidant activity evaluation

M Zuluaga, A BarzegariD Letourneur… - … medicine and cellular …, 2017 - hindawi.com

Page 1. Research Article Oxidative Stress Regulation on Endothelial Cells by Hydrophilic
Astaxanthin Complex: Chemical, Biological, and … Astaxanthin, a xanthophyll carotenoid with high
antioxidant capacities, has been shown to prevent the first stages of oxidative stress …

Save Cite Cited by 24 Related articles All 11 versions 

[HTML] arvojournals.org

[HTML] Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo

K Ohgami, K Shiratori, S Kotake… - … & visual science, 2003 - iovs.arvojournals.org

… doi:https://doi.org/10.1167/iovs.02-0822. Views: Full Article; Figures; Tables. PDF; Share: E-mail;
Facebook; Twitter; Google; Digg; Delicious; Tumblr; StumbleUpon. Tools: Alerts User Alerts. You
are adding an alert for: Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation …

Save Cite Cited by 334 Related articles All 10 versions 

[PDF] researchgate.net

[PDF] Genoprotective properties of astaxanthin revealed by ionizing radiation exposure in vitro on human peripheral blood lymphocytes

MА Pilinska, DА Кurinnyi, SR Rushkovsky… - Засновник …, 2016 - researchgate.net

… 2008. Vol. 590. Р. 387 395. 7. Contribution of the antioxidative property of astaxanthin to its
protective effect on the promotion of cancer metastasis in mice treated with restraint stress/H.
Kurihara, H. Koda, S. Asami, Y. Kiso, T. Tanaka//Life Sci. 2002. Vol. 70. Р. 2509 2520 …

Save Cite Cited by 12 Related articles All 4 versions 

[PDF] researchgate.net

In situ Raman imaging of astaxanthin in a single microalgal cell

A Kaczor, K Turnau, M Baranska - Analyst, 2011 - pubs.rsc.org

… Astaxanthin (AXT, 3,3′-dihydroxy-β,β-carotene-4,4′-dione), a red pigment, chemically classified
as xanthophyll, is a superpotent … capacity of AXT, which is directly related to its protective action
against cardiovascular diseases, immune system ailments and cancer, 6 makes it …

Save Cite Cited by 78 Related articles All 10 versions

Identification of a GDSL lipase from Streptomyces bacillaris and its application in the preparation of free astaxanthin

K Gao, X Wang, H Jiang, J Sun, X Mao - Journal of Biotechnology, 2021 - Elsevier

… PDFDownload. Advanced. Elsevier. Journal of Biotechnology … 1. Introduction. Astaxanthin (Ax),
as a carotenoid pigment molecule, shows strong antioxidant (Yi et al., 2018), anti-cancer (Lee
et al., 2009), and anti-inflammatory (Priyadarshini and Aggarwal, 2018) properties …

Save Cite Cited by 1 Related articles All 4 versions

Production of Microencapsulated Crawfish (Procambarus clarkiiAstaxanthin in Oil by Spray Drying Technology

J Pu, JD Bankston, S Sathivel - Drying Technology, 2011 - Taylor & Francis

… [ 2 ] Supplementation with astaxanthin effectively suppressed carcinogenesis in mice urinary
bladder tissue. [ 3 ] Previous studies have shown that astaxanthin inhibited tumor growth in breast
cancer [ 4 ] and that it prevented oxidative stress [ 5 ] and cardiovascular diseases …

Save Cite Cited by 38 Related articles All 3 versions

[HTML] mdpi.com

Astaxanthin inhibits acetaldehyde-induced cytotoxicity in SH-SY5Y cells by modulating Akt/CREB and p38MAPK/ERK signaling pathways

T Yan, Y Zhao, X Zhang, X Lin - Marine drugs, 2016 - mdpi.com

… Astaxanthin (Ast) is a carotenoid that occurs naturally in a wide variety of organisms such as
microalgae, yeast, salmon, trout … with a number of health-promoting benefits, including
immunomodulation, prevention and treatment of cardiovascular diseases and cancer [20,21,22] …

Save Cite Cited by 41 Related articles All 6 versions 

[PDF] tahomaclinic.com

Neuroprotective effect of astaxanthin on H2O2-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo

YP Lu, SY Liu, H Sun, XM Wu, JJ Li, L Zhu - Brain research, 2010 - Elsevier

… Research Report. Neuroprotective effect of astaxanthin on H 2 O 2 -induced neurotoxicity
in vitro and on focal cerebral ischemia in vivo … Abstract. Astaxanthin (AST) is a powerful
antioxidant that occurs naturally in a wide variety of living organisms …

Save Cite Cited by 117 Related articles All 8 versions

[PDF] researchgate.net

Astaxanthin production by Phaffia rhodozyma and Haematococcus pluvialis: a comparative study

AR Domínguez-Bocanegra, T Ponce-Noyola… - Applied Microbiology …, 2007 - Springer

… Download PDF. Biotechnological Products and Process Engineering; Published: 01 March 2007 …
versions of the pigment were very popular in the1980s, but it was demonstrated that some of
them may induce human cancer (Newsome 1986), and astaxanthin is rather …

Save Cite Cited by 76 Related articles All 18 versions

[HTML] Well-known antioxidants and newcomers in sport nutrition: coenzyme Q10, quercetin, resveratrol, pterostilbene, pycnogenol and astaxanthin

M Belviranli, N Okudan - 2015 - europepmc.org

… It has potential health-promoting effects in the prevention and treatment of various diseases such
as cancer, chronic inflammatory diseases, diabetes, cardiovascular and neurodegenerative
diseases (Yuan et al. 2011). Astaxanthin also has immunomodulating, antiinflammatory …

Save Cite Cited by 31 Related articles All 4 versions 

Comparative assessment on the extraction of carotenoids from microalgal sources: Astaxanthin from H. pluvialis and β-carotene from D. salina

MN Rammuni, TU Ariyadasa, PHV Nimarshana… - Food chemistry, 2019 - Elsevier

… stress; the disturbance in balance between the occurrence of free radicals and the capacity of
the body to detoxify them, leads to several non-infectious diseases including cancer, chronic
inflammation and cardiovascular diseases (Milledge, 2010). Astaxanthin is considered as …

Save Cite Cited by 84 Related articles All 7 versions

[HTML] sciencedirect.com

[HTML] Connexins as targets for cancer chemoprevention and chemotherapy

TJ King, JS Bertram - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier

… Download PDFDownload. Share. Export. Advanced. Elsevier. Biochimica et Biophysica Acta
(BBA) - Biomembranes. Volume 1719, Issues 1–2, 20 December 2005, Pages 146-160.
Biochimica et Biophysica Acta (BBA) - Biomembranes. Review. Connexins as targets for cancer …

Save Cite Cited by 156 Related articles All 8 versions

Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NFκB/SIRT1 pathway and mitigating oxidative stress

H IskenderG YeniceE Dokumacioglu… - … of physiology and …, 2020 - Taylor & Francis

… It regulates major cellular processes, such as cell proliferation, differentiation, aging, gene
expression, cellular metabolic balance, apoptosis, autophagy, cancer, and circadian rhythm
(Poulose and Raju 2015). Astaxanthin (ASX) is naturally found in the shells of sea creatures …

effect against prostate cancer (Gann and Khachik, 2003) … Consumption of ketocarotenoids, most
notably astaxanthin, is also increasingly associated with a range of health benefits …

Save Cite Cited by 116 Related articles All 9 versions

[PDF] academia.edu

Solubility of astaxanthin in supercritical carbon dioxide

HS Youn, MK Roh, A Weber, GT Wilkinson… - Korean Journal of …, 2007 - Springer

… revealed including that of a vitamin A precursor [12], a scavenger and/or quencher of free radicals
and active oxygen [13,14], a preventative against cancer [15,16], and an enhancer of the immune
response systems [17,18]. The quenching effect of astaxanthin for molecular …